Relationship Between Serum Interleukin-10 And Lung Function In Patients With Chronic Obstructive Pulmonary Disease

Objective The essence of chronic obstructive pulmonary disease（COPD）is chronic airway inflammation,and its pathogenesis and progression are mainly due to the infiltration of numerous inflammatory cells and inflammatory factors.In recent years,more and more studies have shown that interleukin-10（IL-10）may be involved in airway protection and plays an important role in it.Lung function can be used to diagnose COPD as well as evaluate the severity of COPD.However,the relationship between IL-10 and lung function is still unclear,so this study aims to explore the relationship between serum IL-10 and lung function in patients with stable COPD,so as to further understand the role of IL-10 in COPD.Methods A total of 124 COPD stable patients,who visited the department of Respiratory and Critical care Medicine of the Third Affiliated Hospital of Anhui Medical University from November 2020 to May 2021 were selected.The basic clinical information of all patients was investigated,including gender,age,height,weight,year of smoking,number of daily smoking,and years of coughing and expectoration.The patients who met the inclusion criteria were tested for serum IL-10 on fasting in the morning of the second day,and the pulmonary function test was completed.After the statistical data,the difference of IL-10 between COPD with different severity was compared,and the diagnostic efficacy of IL-10 for severe COPD and extremely severe COPD was compared.The correlation between serum IL-10 and pulmonary ventilation function,small airway function and smoking index was analyzed.The difference of IL-10 between different diffusion functions was compared to see if there was statistical significance.Results 1.There were no statistically significant differences between Global Initiative for COPD（GOLD）grade III-IV and GOLDI-II in gender,age,disease years,smoking index and body mass index,the serum IL-10 content in GOLDI-II patients was significantly higher than that in GOLDIII-IV patients（7.79±2.02）vs（5.81±1.72）（P<0.001）.Receiver operating characteristic curve was used to analyze the diagnostic efficacy of IL-10 for GOLDIII-IV,and the area under the curve was 0.224.Therefore,the diagnostic efficacy of IL-10 for severe and very severe COPD patients was considered to be poor.2.Comparing IL-10 with indicators reflecting lung ventilation function:The ratio of forced expiratory volume in one second to forced vital capacity（FEV₁/FVC）and predicted value by forced expiratory volume in the first second（FEV₁%pred）and forced vital capacity of predicted value（FVC%pred）.Results showed that IL-10 and FEV1/FVC（r=0.490,P<0.001）,FEV₁%pred（r=0.601,P<0.001）,FVC%pred（r=0.392,P<0.001）were positively correlated.3.Linking IL-10 to indicators of small airway function:forced expiratory flow rates at 50%of vital capacity of predicted value forced expiratory flow rates at 75%of vital capacity of predicted value（FEF75%pred）,maximum expiratory flow between 25%and 75%of vital capacity of predicted value（MMEF%pred）showed that IL-10 and PEF50%pred（r=0.337,P<0.001）,PEF75%pred（r=0.439,P<0.001）,MMEF%pred（r=0.384,P<0.001）were positively correlated.4.For dispersion function,analysis of variance showed no significant difference in IL-10 between different dispersion function groups（P>0.05）.5.The serum IL-10 of patients with heavy smoking history was significantly lower than that of patients without heavy smoking history（6.19±1.85）vs（7.26±2.25）（P=0.004）,and IL-10 was negatively correlated with smoking index（r=-0.188,P=0.037）.Conclusion IL-10,as an important anti-inflammatory factor,is related to the degree of COPD airflow obstruction and small airway function.It may play an important role in the protection of lung function in COPD patients.