| IntroductionPCOS is a major disease that seriously endangers the health,reproductive development and quality of life of women of childbearing age.There is no the best treatment,clinical doctors with western medicine treatment,but western medicine has side effects or reproductive technology the success rate is low,so in the healthcare industry is looking for a more safe and effective drug in the treatment of PCOS.Director of obstetrics and gynecology Xiao-ke Wu led to complete the polycystic ovary syndrome research subject,for the first time found that berberine has a promoting ovulation,improve the curative effect of pregnancy and live birth rates,can be lifted ovarian insulin resistance,promoting ovulation,lowering androgen synthesis.However,there is no evidence of evidence-based medicine.In this paper,the method of meta-analysis was used to evaluate the safety and efficacy of BBR in treating PCOS patients.ObjectiveThe berberine in the treatment of patients with PCOS RCT systematic review and Meta analysis,evaluation of BBR influence on progress in PCOS patients,in order to use the method of evidence-based medicine provide high-level evidence-based medical evidence for clinical practice.MethodsThe computer retrieves the CNKI,VIP,CBM,Wanfang Data,PubMed,and Cochrane Library databases,supplemented the references of the retrieval papers and literature reviews,and traces the unpublished collection of conferences and the compilation of academic papers.The time ended in November 2017.A randomized controlled trial was included in all BBR treatments for PCOS.The intervention measures adopted in the treatment group were single berberine,BBR+CPA,BBR+MET,BBR+IVF(ICSI/IVF)+Lifestyle,BBR+CPA+Lifestyle,BBR+CPA+MET+Lifestyle.The control group was given a single use of CPA,a single MET,a single use of triazole(LET),CPA+MET+Lifestyle,CPA+Lifestyle,placebo(PL)+CPA+Lifestyle,PL+ICSI/IVF+Lifestyle and MET+ICSI/IVF+Lifestyle therapy.Data extraction and analysis method:At the beginning,two evaluators extracted the data independently and extracted the contents one by one.If there were different opinions,it could be discussed by discussion or third parties.The concrete conclusions were presented in the form of Excel form,and the method referred to the relevant instructions of the 5.0.2 edition of the Cochrane collaboration system evaluation manual.The analysis method is Meta analysis using RevMan 5.3 software.I2 test was used for the heterogeneity of the study results.If the heterogeneity test difference was not statistically significant(P>0.10,I<50%),the fixed effect model was used for Meta analysis.When the heterogeneity test difference was statistically significant(P≤0.1),the random effect model was used for Meta analysis.The weighted mean difference(WMD)and its 95%CI were used to express the statistical analysis of curative effect.Outcome indicators:①pregnancy rate,②BMI,③FINS,④FBG,⑤HOMA-IR,⑥TG,⑦T,⑧LDL-C,⑨HDL-C.ResultsIn the 10 articles included,BBR had a certain therapeutic advantage in reducing T,TC,TG,FINS,BMI and FBG of PCOS patients.In pregnancy,BMI,FINS,FBG,HOMA-IR,TG,there is no statistical significance between BBR and MET,and in LDL-C,HDL-C,TC,T in BBR the curative effect of treating PCOS patients have more advantages than MET treatment in patients with PCOS,the difference was statistically significant.In addition,BBR is less responsive in adverse reactions,providing more options for future clinical use.ConclusionBBR has certain treatment of PCOS,and long-term benefits in clinical practice.It can be used as an alternative.LimitationMost of these 10 studies have no follow-up record,and no long-term efficiency is considered.The 10 studies selected are limited to Chinese and English,so there is a selective bias in the literature selection.The outcome index in the included literature is only 3 in the pregnancy rate,which requires further data collection. |
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