The Study Of New Magnetic Resonance Imaging Techniques In Congenital Heart Disease Associated With Pulmonary And Airway Lesions

Objective To explore the application value of three-dimensional turbo field echo(3D-TFE)and three-dimensional ultrashort echo time(3D-UTE)in pulmonary and tracheobronchial anomalies which were associated with congenital heart disease.Methods1.Five bama miniature pigs were enrolled in our study and performed MRI 3D-TFE,3DUTE airway scanning and chest CT scan.Radiologists evaluated the feasibility of 3D-TFE and 3D-UTE in showing tracheobronchial tree.(2)Pneumonia animal models in five bama miniature pigs were made,and underwent MRI 3D-UTE pulmonary scanning and chest CT scan.Compared to CT results,radiologists evaluated the feasibility of 3D-UTE in showing pulmonary lesions.2.Sixty-two consecutive children were enrolled,who were diagnosed congenital heart disease by echocardiography.All children underwent MR examination,including CE-MRA,3D b-TFE,and 3D-TFE sequence.Image quality was objectively evaluated including signal-tonoise ratio,signal intensity and tracheal boundary clarity.Two independent radiologists subjectively evaluated image quality and image noise using a 5-point scale,and analyze the value of 3D-TFE in assessing tracheobronchial anomalies of congenital heart disease.3.We recruited 24 children who were confirmed congenital heart disease by echocardiography.They were referred to cardiac MRI and chest CT examination respectively.3D-UTE sequence was performed to assess tracheobronchial tree,detect tracheobronchial and pulmonary anomalies.Two radiologists in blinded way scored 3D-UTE image quality using 5-point scale independently and analyzed the value of 3D-UTE in assessing tracheobronchial and pulmonary anomalies of congenital heart disease.Results1.3D-TFE and 3D-UTEclearly showed tracheobronchial tree of bama miniature pigs;3DUTE could showed pulmonary anomalies of bama miniature pigs.2.The SNR,signal intensity,tracheal boundary clarity and image quality scores of 3DTFE in trachea was higher than that of CE-MRA and3 D b-TFE.3.The sensitivity,specificity,positive predictive value and negative predictive value of 3D-UTE in detecting tracheobronchial anomalies were100%,88.89%,93.75% and 100% respectively.The results of 3D-UTE pulmonary imaging are consistent with CT images,andthe diagnostic accuracy was 100%.The image quality and diagnostic confidence of 3D-UTE were good.Conclusion The image quality of 3D-TFE sequence for demonstrating tracheobronchial tree is superior to the 3D b-TFE and CE-MRA sequences.3D-UTE sequence could clearly show tracheobronchial structure,accurately detect tracheobronchial and pulmonary anomalies.As essential auxiliary sequences for cardiac magnetic resonance imaging,3D-TFE and 3D-UTE can detect tracheobronchial and pulmonary abnormalities which were associated with congenital heart diseases,and then supply helpful information for preoperative strategies and postoperative follow-up.