| ObjectiveTo explore the distribution of TCM syndromes in non-acute patients of gout patients,and to explore the relationship between TCM syndrome types and xanthine oxidase activity and uric acid metabolism.MethodsPatients with non-acute patients with primary gout were enrolled in the Second People’s Hospital affiliated to Fujian University of Traditional Chinese Medicine from February 2018 to February 2019.Collect patient disease data and detect xanthine oxidase activity,blood uric acid,serum creatinine,urinary and renal function and other indicators.TCM syndrome differentiation by senior doctors to explore the distribution of TCM syndromes in the nonacute phase of gout.Sixteen healthy physical examination patients were included in the control group,and the differences in xanthine oxidase activity and uric acid metabolism between gout patients and control groups were compared.According to the pathological characteristics of the disease,the patients with gout were divided into sthenia-sydrome group,and asthenia-syndrome accompained with sthenia-syndrome group.xanthine oxidase activity and Clinical characteristics were compared between the two groups.Results1.A total of 65 patients with non-acute gout were collected in this study.There were 63 males and 2 females.The male to female ratio was 63:2.The male incidence rate was higher than that of females.2.The distribution of TCM syndromes in 65 patients with gout non-acute phase: 35 cases of spleen-deficiency induced damp obstuction syndrome,17 cases of damp-heat brewing and binding syndrome,11 cases of phlegm and stasis syndrome,and 2 cases of liver and kidney yin deficiency syndrome.There was a statistically significant difference in the distribution of TCM syndromes(P<0.05),the proportion of spleen-deficiency induced damp obstuction syndrome was the highest3.The distribution of uric acid metabolism in 65 patients with gout in the study: 45 cases of uric acid excretion reduction,18 cases of mixed type,and 2 cases of excessive uric acid production.Among the uric acid excretion reduction types,the distribution of TCM syndromes was statistically different(P<0.05),and the spleen-deficiency induced damp obstuction syndrome and damp-heat brewing and binding syndrome were common TCM syndromes.4.The activity of xanthine oxidase in gout patients was significantly higher than that in the control group(P<0.05).The uric acid excretion score of gout patients was significantly lower than that in the control group(P<0.05).5.There was a statistically significant difference in the activity of xanthine oxidase between sthenia-sydrome group and asthenia-syndrome accompained with sthenia-syndrome group(P<0.05).activity of xanthine oxidase in the sthenia-sydrome group was higher than that in asthenia-syndrome accompained with sthenia-syndrome group.xanthine oxidase was a risk factor for sthenia-sydrome by binary logistic regression analysis(P<0.05,OR>1).There was no significant difference in uric acid excretion scores between sthenia-sydrome group and asthenia-syndrome accompained with sthenia-syndrome group(P>0.05).6.There was a significant difference in the distribution of serum uric acid levels between different pathological features(P<0.05).uric acid level of sthenia-sydrome group was higher than that in the asthenia-syndrome accompained with sthenia-syndrome group.7.The age of patients with non-acute gout was statistically different between different pathological features(P<0.05),and the age of patients in the sthenia-sydrome group was higher than that of the asthenia-syndrome accompained with sthenia-syndrome group.8.Disease duration of patients with non-acute gout was statistically different between different pathological features(P<0.05),and disease duration of the tsthenia-sydrome group was longer than that of the asthenia-syndrome accompained with sthenia-syndrome group.9.There was no significant difference in the distribution of low-density lipoprotein,fasting blood glucose,serum creatinine,body mass index,systolic blood pressure,diastolic blood pressure,comorbidities between different pathological features(P>0.05).Conclusions1.Spleen deficiency and dampness obstruction syndrome is most common in the nonacute phase of gout.2.Uric acid excretion reduction type is the most common type of abnormal uric acid metabolism.In the uric acid excretion reduction type,spleen deficiency and dampness obstruction syndrome and damp-heat brewing andbinding syndrome are common TCM syndrome type.3.this study shows that xanthine oxidase activity is a risk factor for sthenia-sydrome,and those with high xanthine oxidase activity tend to be sthenia-sydrome. |
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