| Objects:The aim of part is to study the structural and mechanism of interaction between TOM1 and TOLLIP which are involving inflammation,learn more about the specific structure of these two proteins,thus provide information for inflammatory signaling transduction of inflammation and the following drug development.the purpose of part 2 is to study the effects of elastic modulus changes of dental implants on the stress distribution in the implants and periimplant tissues,providing more experimental basis for the further research of new dental implant system.Method: The interaction between TOM1 protein and TOLLIP protein was studied by using analytical molecular sieves,isothermal titration calrimetry,analytical ultracentrifugation.The structure of the protein was analyzed by Xray diffraction Method The 3-D finite element analysis models of a mandible segment with an implant bone was constructed.The elastic modulus of implants were set as 110 GPa,90GPa,70 GPa,55GPa and 40 GPa.The strain value was loaded the force of 300 N vertically,100 N horizontal and 130 N in the angle of approximately 30°with the occlusal plane.Analyze stress of different elastic implants and hard tissues around screw implants under different loads.Results: A variety of experimental results can prove that there is a definite interaction between TOM1 protein and TOLLIP protein,the structure of C2 domain was solved successfully.Stress in the cortical bone around implants,also the stress through the implants were both decreased as the elastic modulus of implants declined.Conclusion: There is a definite interaction between TOM1 protein and TOLLIP protein.Reducing elastic modulus of implants can benefit the transferring of functional load through the implants and to the surrounding bone,and is a promising way to decrease the risk of implants failure after force loaded. |
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