Study On Correlation Between TCM Syndromes Of Watershed Cerebral Infarction And The Degree Of Vascular Stenosis And Carotid Plaque Stability

Objective:To analyze the Correlation between TCM Syndromes of watershed cerebral infarction and cerebral vascular stenosis and carotid plaque stability.Methods:176 patients with acute CWI who were hospitalized in the Department of Encephalopathy of Tai’an Hospital of Traditional Chinese Medicine from April 2018 to December 2018 and confirmed by diffusion weighted imaging(DWI)and clinical diagnosis were divided into different groups according to TCM syndromes.The general information of the patients was collected and the degree and branch number of stenosis in internal carotid artery system and carotid plaque stability were recorded.SPSS16.0 software was used for statistical analysis.Results:1.According to the composition ratio of TCM syndromes,176 patients in this study ranked from high to low as follows:58 cases(33.0%)of wind-phlegm-stasis syndrome,46 cases(26.1%)of Qi-deficiency and blood-stasis syndrome,42 cases(23.9%)of phlegm-heat-fu organ constipation syndrome,30 cases(17.0%)of Yin-deficiency and wind-movement syndrome.There was no significant difference in gender,age and past history among the four groups(P>0.05).2.There were 129 cases(73.3%)with moderate or more vascular stenosis in 176 patients with acute CWI.There were significant differences in the degree of internal vascular stenosis in TCM syndrome groups(P<0.05).By comparison,there were significant differences in the degree of vascular stenosis between phlegm-heat-fu organ constipation group and wind-phlegm-stasis group,phlegm-heat-fu organ constipation group and Qi-deficiency-blood stasis group(P<0.0083).There was no significant difference in the degree of vascular stenosis between Yin-deficiency and wind-movement group and other syndrome groups,wind-phlegm-stasis group and Qi-deficiency and blood-stasis group(P>0.0083).3.Among 176 patients with acute CWI,113(64.2%)had multiple vessel stenosis.There was no significant difference in the number of stenosis branches in TCM syndrome groups(P>0.05).4.Among 176 patients with acute CWI,83 cases(47.2%)were found carotid unstable plaque.There were significant differences in the detection rate of unstable plaque in TCM syndrome groups(P<0.05).Taking the phlegm-heat-fu organ constipation group as the control group,the other groups were compared with it.The detection rates of unstable plaques in phlegm-heat-fu organ constipation group and Qi-deficiency and blood-stasis group,phlegm-heat-fu organ constipation group and wind-phlegm-blood stasis group were significantly different(P<0.017).There was no significant difference in the detection rate of unstable plaque between phlegm-heat-fu organ constipation group and Yin-deficiency and wind-movemen group(P>0.017).Conclusion:1.The main manifestation of CWI in acute stage is wind-phlegm-stasis syndrome,followed by Qi-deficiency-blood-stasis syndrome.2.Moderate or more multiple vessel stenosis is more common in acute CWI.3.In acute CWI,the degree of vascular stenosis of wind-phlegm-stasis syndrome and Qi-deficiency and blood-stasis syndrome is relatively heavier,and the unstable plaque is easier to be detected in phlegm-heat-fu organ constipation syndrome.It can not be considered that the difference of the degree of stenosis and the detection rate of unstable plaque in Yin-deficiency and wind-movement syndrome are different from the other syndromes.