Clinical Research On Effects Of She Xiang Si Huang Granules On Top Of Basilar Artery Syndrome Of Wind And Phlegm Blockage Channel

Objective:To observe the clinical efficacy of She Xiang Si Huang Granule in the treatment of top of basilar artery syndrome of wind and Phlegm blockage channel type,and observe the improvement of nerve defect and activity of daily living.Applying the basic theory of TCM to explore the etiology and Pathogenesis of the top of the basilar syndrome,in order to provide a new method for the clinical treatment of this disease.Methods:Choose 64 Patients from November 2017 to November 2018 in the Traditional Chinese Medicine Hospital of Wei Fang who were diagnosed with top of basilar artery syndrome of wind and Phlegm blockage channel type,were divided into 2 groups randomly:treatment group and control group,32 cases in each group.Both treatment group and control group follow the Guidelines for diagnosis and treatment of acute ischemic stroke in China 2014,were treated with standard western medicine.The treatment group was treated with She Xiang Si Huang Granules on the basis of routine western medicine treatment,a dose,2 times a day,once in the morning and night,drink with boiled warm water,observed for 14 days.After the end of treatment,compared the NIHSS score,activity of daily living(improved Barthel index)score,TCM syndrome score,effectiveness on the degree of neurological deficit,curative effect of TCM syndrome and safety index including routine blood test and liver function test of two groups before and after treatment7 and 14 days.Analyze the clinical efficacy after statistical analysis.All data were input by Excel and analyzed by SPSS20.0 statistical software.Measuring data conforming to normal distribution were tested by t test,paired sample t test was used for intra-group comparison,independent sample t test was used for inter-group comparison,to express the data by using The mean ± standard deviation.Rank sum test was used for measurement data and grade data which did not conform to the normality,Chi-square test was used for counting data.Pwas bilateral test,P<0.05 had significant difference,P<0.01 had extremely statistical significance.Results:2 cases were shedding,one from the treatment group and the other from the control group.Finally,each group was completed with 30 cases.The total effective rate of TCM syndrome was 96.67%in the treatment group,76.67%in the control group,and the effective rate of the degree of neurological deficit was 96.67%in the treatment group and 93.33%in the control group.As for curative effect of TCM syndrome and effectiveness on the degree of neurological deficit,there was significant difference between the treatment group and the control group(P<0.01),and the treatment group was better than the control group.In terms of NIHSS score,activity of daily living(improved Barthel index)score,TCM syndrome score,the scores of 14 days and 7 days were better than before treatment.AT the same time,the scores of 14 days were better than 7 days,the treatment group was better than the control group.The difference makes sense(P<0.05).There were no significant changes in blood routine,liver function and other safety indicators in the two groups.There’s no adverse reactions were founded during the treatment.Conclusion:She Xiang Si Huang Granule can improve the degree of nerve function defect,daily living ability and prognosis of patients with wind and phlegm blockage channel of top of basilar artery syndrome.It also can improve clinical symptoms and symptoms.It can be safely applied in clinic because of it has no obvious toxic and side effects.It is worthy of further promotion and research.