Clinical Significance Of Chemokine(C-X-C Motif) Ligand 17 And Receptor 8 Expression In Colon Cancer Patients

ObjectiveThis study aims to explore the correlation between the expression of CXCL17 and CXCR8(GPR35)in colon cancer and the clinicopathological characteristics and the prognosis of patients,so as to provide a new idea for the prognostic assessment and treatment of colon cancer.MethodsIn the presentstudy,the expression of CXCL17 and CXCR8 was investigated in 101 coloncancer tissues and 79 normal tumor-adjacent tissues by IHC,and thecorrelation between the expression levels of CXCL17 and CXCR8 andclinical pathological characteristics and overall survival of colon cancer patients were analyzed with Pearson chi square test and Spearman correlation analysis.Survival probabilities were estimated using the Kaplan-Meier and Log-rank test.Univariate and multivariate Cox proportional hazards regression models were applied to assess the association of potential confounding variables with prognosis.Results1.Immunohistochemical(IHC)staining of CXCL17 and CXCR8 in the colon cancer tissue microarray(TMA)showed a significant increase in the colon cancer tissues compared with the tumor-adjacent tissues.2.No significant correlation was found between high expression of CXCL17 and CXCR8 in colon cancer tissues and patients’ age,gender,tumor type,lymph node metastasis,histological grade,tumor invasion depth,and TNM stage.3.Kaplan-meier analysis showed that patients with higher CXCL17 expression had longer overall survival.The expression of CXCR8 was an independent prognostic factor for patients with colon cancer.4.The expression of CXCL17 was positively correlated with the expression of CXCR8(GPR35)in colon cancer tissues.The patients with combined high expression of CXCL17 and CXCR8 in colon cancers of TNMⅠ-Ⅱ had a higher survival rate than those without combined high expression.Combined high expression of CXCL17 and CXCR8 was an independent prognostic factor for patients with colon cancer.ConclusionsThe present study indicates that CXCL17-CXCR8 signaling is involved in colon cancerand contributes to a better prognosis.