Correlation Between Clinical And Pathological Characteristics Of Mixed Ground-glass Nodules

Objective:To retrospectively analyze the clinical data and pathological results of patients with isolated mixed ground glass nodules,to screen out the risk factors of malignant pulmonary nodules,and to provide a basis for the diagnosis and treatment of patients with isolated mixed ground glass nodules.Methods:Patients with isolated mixed ground-glass nodules who underwent surgical treatment from January 2017 to January 2019 in thoracic surgery were selected.Divided into benign group(n=33)and malignant group(n=226)according to routine pathological results after surgery.Collect clinical data of patients:gender,age,smoking history,history of malignant tumors,family history of malignant tumors,history of diabetes,chronic respiratory disease history,9 tumor markers,lung lobe where the nodule is,diameter and CT value,shape,border,burr sign,lobulation sign,calcification,pleural depression or traction,vascular bundle or blood vessel Crossing,air bronchi sign or vacuole sign.Screening for risk factors for isolated mixed groundglass nodules.Results:Univariate analysis of personal malignant tumor history,family lung cancer history,non-lung cancer family malignant tumor history,diabetes,chronic respiratory disease history,age,gender,9 tumor markers and smoking history were no different between benign and malignant nodules.The maximum diameter of the nodule(15.63 ± 6.86mm),the nodule is located in the right lung,vascular passage or vascular bundle,air bronchial or vacuolar sign,lobulated sign,burr sign will increase the risk of nodules,Patients with invasive adenocarcinoma were significantly older than patients with carcinoma in situ and microinvasive adenocarcinoma at the age of onset,the largest CT value and the largest diameter of nodules.The maximum CT value of the 1mm layer thickness is greater than that of the 5mm layer thickness.Conclusion:Larger nodule diameter(15.63±6.86mm),nodule located in the right lung,vascular passage or vascular bundle,air bronchial or vacuolar sign,lobulated sign,burr sign increase the malignant risk of the pulmonary nodules.The maximum CT value,maximum diameter and age of onset of nodules in patients with invasive adenocarcinoma were significantly greater than those in carcinoma in situ and microinvasive adenocarcinoma.The maximum CT value of the nodule with a thickness of 1mm was greater than the thickness of 5mm.CT imaging is an effective method to distinguish benign and malignant mixed ground-glass nodules.