Observation On The Efficacy Of HAART Regimen With EFV Eduction In Methadone Maintenance Treatment Population

Objective1.To understand the effect of reducing the daily dose of EFV on the lymphoid T cells,viral load,blood routine test,liver and kidney function.2.To make clear the change trend of methadone in clinical after reducing the dosage of EFV in AIDS patients with methadone maintenance therapy（MMT/HIV）,so as to provide theoretical basis for further optimization of domestic treatment guidelines and treatment manuals.Method1.According to the strict inclusion and exclusion criteria,34 participants were selected to meet the requirements.They were assessed with the suicide risk assessment scale andHamilton Depression Inhibition Scale before and 12 weeks after EFV was reduced to400mg/D（baseline）by face-to-face,one-to-one inquiry2.The blood samples of 34 participants were collected for lymphoid T cells,viral load,blood routine test,liver and kidney function test,and the results were statistically analyzed.The blood samples were collected from 8:00 to 10:00 in the morning of the 4th and 12thweek after baseline and reduction,and then sent to the laboratory of the second people’s Hospital of Dali City for test,with 93 blood samples in total.3.The daily dose of methadone was recorded by telephone or face-to-face inquiry.4.Import the collected data into Spss17.0 statistical software package,Statistical analysis,the methods mainly include t test and variance analysis.Result1.The average age（mean±SD）of 34 participants was 46.12±5.91 years old,and the weight（mean±SD）was 54.21±4.98kg.Among them,26（76.47%）were male,22（64.71%）were Han,and 22（64.71%）were junior high school students.Most of them were married,18（52.94%）were married.2.At baseline and the 12th week after EFV reduction,the results of suicide riskassessment scale and Hamilton Depression Scale showed that there was a difference in the evaluation results of Hamilton Depression Scale（t=8.786,P<0.001）,and there was no statistical difference in the evaluation results of suicide risk assessment scale.3.In this study,it was found that there was no significant change in CD₄⁺Tlymphocytes（F=1.348,P=0.265）,no significant difference in the ratio of CD₄⁺T to CD₈⁺T lymphocytes（F=0.038,P=0.963）,and the equivalence test results of CD₄⁺Tlymphocytes were T₁=2.5025（P₁<0.05）,T₂=11.512（P₂<0.05）.4.Among the 18 blood routine monitoring indexes,3 indexes showed statistical significance.The three indexes were mean hemoglobin concentration（F=16.471,P<0.001）,platelet（F=3349,P=0.04）,platelet distribution width（F=3996,P=0.022）,Among them,the detection value of the average hemoglobin concentration showed a trend of first rising and then declining,the platelet showed a trend of first falling and then rising,the platelet distribution width showed a trend of declining,but within 12 weeks,thedetection results of these three indicators were within the safety limit.There was nosignificant difference in the other 15 blood routine test indexes.In addition,there was no significant difference in the results of 5 blood biochemical indexes according to the level ofα=0.05.5.At baseline,the average dose of methadone was 110.15ml/d.After EFV reduction,the daily dose of methadone decreased slowly with time.After 12 weeks,the average dose was 80.69ml/d,33.987%,and the reference range of 95%reduction was 24.889%-46.324%.ConclusionIn the MMT/HIV population whose body weight is less than or equal to 60kg,EFV dose reduction to 400mg/D has no significant effect on lymphoid T cells,viral load,liver and kidney function.The average dose of methadone decreased by 33.987%（24.889%,46.324%）in 12 weeks,and drug-related side effects（depression）were significantly improved.