Influence Of Two Endometrial Preparation Programs On The Outcome Of The First Frozen-thawed Blastocyst Transfer Cycle In Patients With Whole Embryo Cryopreservation To Prevent OHSS

Objective: To explore the Influence of natural cycle(NC)Programs and hormone replacement cycle(HRT)Programs on the outcome of the first frozen-thawed blastocyst transfer cycle in Patients with whole embryo cryopreservation to prevent ovarian hyperstimulation syndrome(OHSS),and Provide a theoretical basis for clinicians to choose the appropriate endometrial preparation Programs.Methods: This is a retrospective cohort study conducted at the Reproductive Center of the First Affiliated Hospital of Guangxi Medical University.The time was selected from January 2017 to August 2019,data were collected from 112 patients younger than 35 years of age.These patients were subjected to whole embryo freezing due to prevention of OHSS,and frozen blastocyst transplantation was performed for the first time.The patients were divided into NC group(60 cases)and HRT group(52 cases)according to different endometrial preparation programs,and the pregnancy outcomes of the two programs were compared.Results: compared with the biochemical pregnancy rate(86.7% VS 86.5%),embryo implantation rate(52.9% VS55.8%),clinical pregnancy rate(80.0% VS 75.0%),ectopic pregnancy rate(4.2%VS 5.1%),multiple pregnancy rate(30.4% VS 27.0%)and early abortion rate(10.4% VS 2.6%)in 60 NC group and 52 HRT group.the difference was not statistically significant(P> 0.05).Conclusion: For patients whose age is less than35 years old and had undergone whole embryo cryopreservation to prevent OHSS,the two transplanted endometrial preparations achieved similar pregnancy outcomes during the first freeze-thaw blastocyst transfer.