Correlation Between D-dimer,Right-to-left Shunt And Cryptogenic Stroke In Patients With Patent Foramen Ovale

Purpose: The objective of this study is to investigate the correlation between D-dimer,right-to-left shunt and cryptogenic stroke in patients with patent foramen ovale(PFO)by screening the risk ischemic stroke factors of in PFO patients.Methods: Hospitalized patients diagnosed with PFO in our hospital from January 2017 to June 2019 were included in this study.Basic characteristics,past medical history,test results during hospitalization and imaging data of the patients were collected by querying the electronic medical records.The study subjects were selected according to the inclusion and exclusion criteria,the endpoint of this study was defined as the occurrence of cryptogenic stroke.The collected data were statistically analyzed to find possibly significant risk factors by chi-square test and independent sample t-test,and further multivariate logistic regression analysis was performed to exclude confounding factors.Results: A total of 165 patients with PFO were enrolled in this study,including77 male patients and 88 female patients,with the mean age of 44.5 years.There were86 patients with cryptogenic stroke(stroke group)and 79 patients without cryptogenic stroke(non-stroke group).The results showed that compared with 7.6% of those patients in the non-stroke group,the high D-dimer level occurred in 27.9% of those patients in the stroke group(odds ratio,5.47;95%confidence interval [CI],1.74 to17.20;P = 0.010);compared with 27.8% of those patients in the non-stroke group,the permanent right-to-left shunt occurred in 72.1% of those patients in the stroke group(OR,6.92;95% CI,2.97 to 16.15;P <0.001).These results were statistical significance.In summary,we conclude that high plasma D-dimer levels and permanent right-to-left shunt are independent risk factors for cryptogenic stroke in patients with PFO.Conclusion: Elevated D-dimer level or permanent right-to-left shunt in patients with PFO is closely related to the occurrence of cryptogenic stroke,increasing the riskof ischemic stroke,and these patients should be treated early to prevent stroke.