| Objective This study evaluated whether 18F-FDG PET/CT,in comparison with routine bone marrow examination,is useful for the detection of BMI and predictive of outcome.Methods The clinical data of 168 patients with DLBCL were obtained from Fujian Medical University Union Hospital from March 2014 to December 2018.The Statistical factors of the clinical data included patients,gender,age,Ann Arbor stage,B symptom,LDH level,IPI scores,Bone marrow infiltration detected by 18F-FDG PET/CT,Bone marrow infiltration detected by bone marrow infiltration,and so on.The progression-free survival rate and overall survival rate were analyzed by Kaplan Meier estimation,logarithmic grade and Cox proportional hazard regression model.All results were tested by two-sided test,P values less than 0.05 were considered significant.Results 1.In univariate analysis,the risk factors for both PFS and OS included age above 60 years,Ann Arbor stage III/IV,presence of B symptoms,LDH above 245U/L,IPI score above 2 points,bone marrow infiltration diagnosis positive by routine bone marrow examination,bone marrow infiltration diagnosis positive by 18F-FDG PET/CT.By multivariate analysis,an IPI score>2 points,BMI positive according to 18F-FDG PET/CT remained predictive predictive factors of PFS.2.For newly treated DLBCL patients with Ann Arbor stage IV,patients with positive diagnosis of bone marrow infiltration by 18F-FDG PET/CT have a worse prognosis than patients with negative results.3.In multivariate analysis,IPI>2 and 18F-FDG PET/CT diagnosis of bone marrow infiltration are independent risk factors for PFS in newly treated DLBCL patients（P<0.05）,while 18F-FDG PET/CT diagnosis of BMI positive is not an independent factor of OS.Conclusion BMI detected by 18F-FDG PET/CT are independent predictive factors of DLBCL patients.Routine bone marrow aspiration cannot increase the relative diagnostic or prognostic value of 18F-FDG PET/CT alone. |
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