A Comparative Study Of HRCT Findings And Pathology Of Cystic Lung Cancer

Objective Through the analysis of HRCT signs,pathological types and manifestations of 51 cases of cystic lung cancer,we can improve the understanding some tumor signs,and explore the pathological mechanism of cystic lung cancer.Materials and methods A retrospective analysis from January 2010 to December 2019,51 cases of cystic lung cancer confirmed by pathology were analyzed retrospectively.The clinical and imaging data were collected and analyzed,including the age,gender and clinical symptoms of the patients.The imaging data mainly analyzed the location of the lesions,the size of the lesions,the shape of the cystic cavity,the inner wall of the cystic cavity and the peripheral image of the cystic cavity,and compared with the pathological manifestations,so as to observe and study the pathological basis of the formation of the cystic cavity.The measurement data were in accordance with the normal distribution((?)±s)and variance analysis was used to compare the difference of sample mean between two groups;the non-conforming normal distribution was in M(P25,p75)and the comparison between groups was in rank sum test;the count data is in(%),and the percentage or constituent ratio is in 2 test.Multiple logistic regression was used to analyze the relationship between the imaging signs and pathological types.The test level α = 0.05,P < 0.05 was statistically significant.Results There were 51 patients in this group,37 male and 14 female.The patients were aged 24-83 years,with an average age of 56 years.Except for 20 patients who came to the hospital for respiratory system symptoms,the rest were found incidently.These respiratory system symptoms were mainly cough,expectoration,occasionally with blood or fever in the sputum.All of the 51 patients were single focus,of which 13 cases(25.4%)occurred in the upper lobe of the right lung 3 cases(5.8%)in the middle lobe of the right lung,15 cases(29.4%)in the right lower lobe,11 cases(21.5%)in the left upper lobe and 9 cases(17.6%)in the left lower lobe.There was no significant difference in the location of the disease.The size of the lesion ranged from 1.95cm2 to 18.55cm2,and the difference between the size of the lesion and the pathological type was p < 0.05,which was statistically significant.51 cases(100%),48 cases(91.1%),38 cases(74.5%),36 cases(70.5%),13 cases(25.5%),25 cases(49.1%)and 40 cases(78.4%)showed lobular sign,burr sign,pleural indentation sign,irregular shape of the cystic cavity,vessels in the cavity,internal wall nodule.There were 4 cases of adenosquamous carcinoma(7.8%),4 cases of squamous carcinoma(7.8%),43 cases of adenocarcinoma(84.6%).51 cases were divided into three groups according to pathology: A,B and C,group A represents adenosquamous carcinoma,group B represents squamous carcinoma,and group C represents adenocarcinoma.The analysis of the difference between the three groups showed that the Fisher’s accurate probability test statistic was 47.009,and the difference of different pathological composition ratios between groups a,B and C was statistically significant(P < 0.05).There was no significant difference between image classification and pathology.Pathologically,the normal alveolar wall was replaced by tumor cells,and the alveolar wall was destroyed and fused to form a cystic cavity.Conclusion The majority of cystic lung cancer is adenocarcinoma.On CT images,there are typical signs of peripheral lung cancer.The main pathological mechanism of cystic formation is that the tumor grows along the alveolar wall or bronchiole,and forms one-way valve flap.The pressure in the alveoli increases gradually,which leads to the destruction and fusion of the alveoli wall and the formation of cystic cavity.Cystic lung cancer is usually the early stage of tumor growth.If the lesions continue to develop,solid nodules or masses will eventually form.