Development Of Wrist Wearable Multi-parameter Sleep And Respiratory Monitoring System

Sleep disordered breathing(SDB)is generally a more common disease,of which the incidence of obstructive sleep apnea hypopnea syndrome(OSAHS)is the highest,and the root causes of many chronic diseases are related to it.Polysomnography(PSG)is widely used in the diagnosis of sleep disorders and is the "gold standard" for the diagnosis of SDB.This device uses a large number of electrodes,has poor convenience and high price.Also,it is limited by professional personnel and other factors,and it has complex operations,which cannot meet the needs of many users.Therefore,this thesis on how to design and implement a model for household wrist wearable multi-parameter sleep monitoring system is introduced,the system can be used to diagnose the SDB related classification,and the patient’s illness,can monitor multiple vital signs parameters,and improved the traditional detection method of vital signs parameters,full consideration to the user’s point of view of the sensor rational selection,the reasonable design of the circuit,and the rational use of resources,make sure that you can try not to affect the type of sleep quality case for effective screening of SDB subjects.This thesis designs and implements a wearable multi-physiological parameter sleep breathing monitoring system.The following is the main content of the thesis.Firstly,according to the classification in SDB and the clinical diagnostic criteria for related classification of diseases,a wearable wrist monitoring system was developed to combine physiological signals such as snoring,oral and nasal respiratory airflow,chest and abdomen respiratory movement,ECG,blood oxygen saturation,pulse rate,and body temperature.To achieve a more comprehensive and accurate diagnosis of SDB screening,the system realizes the synchronous monitoring of multiple parameters and the mixing of multiple parameter algorithms.The main work of this paper is divided into hardware design parts,upper and lower computer software part and algorithm parts.The hardware design part realizes the synchronous monitoring of multiple physiological parameters of the human body and can supportthe function of data compatible serial port or wireless transmission and storage.New international pressure sensors were used to measure the airflow and snore signals,and two pressure sensors were used to detect the respiratory movement signals in the chest and abdomen.TI’s integrated blood oxygen chip,ECG and temperature sensor chip are used to collect the blood oxygen,ECG and temperature signals of the human body.OSRAM’s blood oxygen probe or the standard disposable finger clip blood oxygen probe are combined to achieve compatible transmission and reflection blood oxygen monitoring.The micro-oled of the East Rising company was used to display the relevant signals in real-time.The nrf52832 with control and Bluetooth function from the Nordic company was used as the main control chip.The upper and lower part mainly includes the lower part,the upper part,and the android APP part.Among them,the lower part mainly includes the peripheral drive circuit,as well as the data collection,preprocessing,storage,wireless transmission to the PC terminal and the mobile phone APP terminal.The upper computer is divided into the construction of sleep monitoring real-time display software and sleep quality evaluation software,which mainly realizes the real-time display,storage,playback,calculation of related parameters,disease diagnosis and evaluation report output of signals.Android APP mainly includes the real-time display of data,display of key parameters,storage,night sleep analysis,and display of sleep quality evaluation results.In the part of the algorithm,feature points were extracted,special events were found,parameters were calculated,and the multi-mode algorithm was combined for a comprehensive analysis of physiological parameters such as respiration,blood sample,ECG,and body temperature.In combination with clinical diagnostic criteria,effective screening and preliminary diagnosis of SDB were conducted.This thesis compares and verifies the physiological signal acquisition of each channel and the relevant standard equipment.Firstly,Fluke’s blood oxygen simulator and ECG simulator were used to verify the accuracy of blood oxygen saturation and ECG module respectively.A mercury thermometer of a certain company was used to verify the accuracy of the temperature part.Second using a company M108 core electricity,blood oxygen,breathing and body temperature monitoring module as forthis system to verify the reference device,verify the randomly selected 10 volunteers,during the process of each volunteers collect altogether 60 minutes of breathing data effectively,calculation of breathing concerning for the accuracy,each channel signal is one of the most basic through the calculation of mean square deviation of the index parameters to judge the accuracy of this system;Using other laboratory silencing rooms and recording equipment as reference for the accuracy verification of snore detection channel signals,the system,and microphone in this paper can monitor snore simultaneously.The verification results show that the snore signals collected by the system and the microphone are accurate.After verification,to ensure the accuracy of the signal collection in each channel,16 volunteers were randomly selected and monitored for overnight sleep data.The collected data were processed and the relevant sleep breathing events were analyzed automatically and manually.According to the standard of sleep respiratory events,the system was classified by manual and automatic analysis,and the relevant parameters were calculated and compared.The result showed that the accuracy rate of SDB diagnosis by the system was up to 93.7%.In conclusion,this system can realize the doctor in SDB disease preliminary screening on auxiliary automatically,and can output a series of related sleep quality evaluation indicators,through the wireless transmission mode,provides convenience for further clinical diagnosis,laid a solid foundation for the development of the health,but also for sleep apnea monitoring provides an innovative idea of further development.