Clinical Study Of Modified Gubenlichang Decoction Combined With Chemotherapy In Middle And Advanced Colon Cancer (Spleen And Kidney Deficiency Type)

Object: By evaluating the clinical efficacy and safety of modified Gubenlichang prescription combined with FOLFOX4(oxaliplatin+calcium folinate + 5-fluorouracil)in the treatment of middle and advanced colon cancer(spleen and kidney deficiency syndrome),so as to provide more theoretical support and empirical reference for the clinical application of Gubenlichang decoction.Methods: The chosen 72 subject with middle and advanced colon cancer(spleen and kidney deficiency syndrome)were divided equally into treatment group(n=36)and control group(n=36).The treatment group was treated with modified Gubenlichang decoction combined with chemotherapy,the control group was given FOLFOX4 chemotherapy alone.Fourteen-days was defined as 1 cycle.Treatment needs to be continued 4 cycles.The syndrome integral of TCM,functional status score(KPS),tumor size,toxic and side effects of chemotherapy,tumor markers,blood routine,liver function and kidney function indexes were statistically analyzed before and after treatment in the two groups.Result:(1)After treatment,the TCM syndrome integral of the two groups were all lower than before(P < 0.01),and both groups had certain curative effect in improving the TCM syndrome of patients.The effective rate in the observation group was83.33%,and that in the control group was 55.56%.The effective rate in the observation group was higher than that in the control group(P < 0.05).The improvement of TCM syndromes in the observation group was better than that in the control group(P < 0.05).(2)Functional status score of the observation group was increased compared with that before treatment(P < 0.05),31 cases in the observation group were effective after treatment(increased + stable),23 cases in the control groupwere effective,and the effective rate in the observation group was higher than that in the control group(P < 0.05).(3)The tumor size of both groups decreased after treatment(P < 0.05),but there was no statistically significant difference in the lesion efficiency between the two groups(P > 0.05).(4)After treatment,CA199 in the observation group was significantly lower than that in the control group(P < 0.01),and there was no significant difference between the two groups in the effect of treatment on CEA(P > 0.05).(5)The side reaction of observation group was lower than those of control group(P < 0.05).But the two groups in Ⅲ ～ Ⅳdegree differences of the influence in the incidence of adverse reaction has no statistical significance(P >0.05)(6)The effect on blood routine,liver function and creatinine of renal function in the observation group was smaller than that in the control group(P < 0.05),and there was no significant difference between the two groups on BUN(P > 0.05).Conclusion:The combination of modified Gubenlichang decoction with FOLFOX4 chemotherapy in the treatment of middle and advanced colon cancer(spleen and kidney deficiency type)can reduce the TCM syndrome integral of patients and improve the KPS score,so as to alleviate the clinical symptoms of patients and improve their quality of life.At the same time,part of tumor markers were reduced(CA199),to a certain extent to reduce the toxic and side effects of chemotherapy,with better safety.It has the clinical effect of enhancing effect and reducing toxicity.