The Research Of(5 + 2) Cycloaddition Reaction With Alleneamides And Alkoxyallenes

There are a large number of natural products with a seven-membered bridge ring core skeleton in nature,and many seven-membered bridged ring natural products have important biological activities and potential medicinal value.However,the construction of the seven-membered bridge ring system has always been a difficult point in the field of organic synthesis.Therefore,the methodology for developing and constructing a seven-membered bridge ring system is of great significance for promoting the synthesis of natural products of seven-membered bridge rings and other complex products.The article mainly consists of two parts,one is the review part,and the other is the experimental part.The review section focuses on the research progress of(5 + 2)cycloaddition reaction methodology and allenamides,alkoxyallenes.The experimental part mainly introduces the rapid construction of the seven-membered bridge ring molecular skeleton by(5 + 2)cycloaddition of alleneamide and alkoxyallenes.In addition,the allene compounds contain two orthogonal double bonds.By changing the substituents of the allene compound and then performing the(5 + 2)cycloaddition reaction,a seven-membered bridge ring compound with different chemical selectivity and regioselectivity can be obtained.