Clinical Study Of Yishen Huoxue Decoction In Treating Post-stroke Depression(kidney Deficiency And Blood Stasis Syndrome)

Objective:This topic focuses on the etiology and pathogenesis of post-stroke depression of kidney deficiency and blood stasis type,and selects Yishen Huoxue Decoction to treat post-stroke depression of kidney deficiency and blood stasis type,and observes the effectiveness and safety of Yishen Huoxue Decoction in treatment through clinical research.To provide objective basis for the treatment of post-stroke depression of kidney deficiency and blood stasis and its new diagnosis and treatment ideas.Methods: In this subject,the 66 patients included were divided into the test group and the control group by the "random number table method".The test group was treated with Yishen Huoxue Decoction and the control group was treated with sertraline hydrochloride tablets.Observe and evaluate the TCM syndrome observation table,Hamilton Depression Scale(HAMD),Modified Rankin Scale(m RS),daily routine before and after treatment,after 4 weeks of treatment and after 8 weeks of treatment Changes in the scores of the Living Ability Rating Scale (ADL),the National Institutes of Health Stroke Scale (NIHSS),and the blood,urine,stool routine,liver and kidney functions,and electrocardiogram of the two groups of patients were also measured.SPSS23.0 was used to analyze the data and compare the efficacy and safety of the two groups.Results: After statistical analysis: 1.Before treatment,the general data of the two groups,including age,gender,TCM syndrome score,HAMD score,Mrs score,ADL score and NIHSS score,had no significant statistical difference(P > 0.05).2.After 4 and 8 weeks of treatment,compared with before treatment,the TCM syndrome score,HAMD score,NIHSS score and Mrs score of the two groups were significantly reduced,and the ADL score was significantly increased(P<0.01).3.After 4 weeks of treatment,the score of TCM syndromes in the test group was lower than that in the control group,but the difference was not statistically significant(P>0.05).After 8 weeks of treatment,the overall evaluation of the efficacy of TCM syndromes in the two groups of patients The total effective rate was 86.67%,and the total effective rate in the control group was 70.97%.The clinical efficacy of the experimental group was better than that of the control group,and the difference was statistically significant (P <0.05).4.After 4 and 8 weeks of treatment,the HAMD scores in the experimental group were lower than those in the control group,but the difference was not statistically significant(P> 0.05).The effective rate was 86.67%,and the total effective rate in the control group was 83.87%,with no significant difference(P>0.05).5.After 4 weeks of treatment,although the NIHSS score of the experimental group was lower than the control group,although the ADL score was higher than the control group,the difference was not statistically significant(P> 0.05);after 8 weeks of treatment,the difference between the two groups was statistically significant.(P <0.05),the clinical effect of the experimental group was better than the control group.6.After 4 weeks and 8 weeks of treatment,the m RS scores of the two groups were tested by rank sum test,and the difference was statistically significant (P <0.05).The clinical efficacy of the experimental group was better than that of the control group.7.During the test,the three routine,liver and kidney functions,electrocardiogram and other indicators of the two groups of patients did not change significantly compared with before entering the group,but the adverse reactions in the test group were significantly less than the control group,and the safety was higher.Conclusion: Yishen Huoxue Decoction is better than sertraline hydrochloride tablets in the treatment of PSD patients with kidney deficiency and blood stasis.It has fewer side effects and high safety,and is worthy of clinical promotion.