Study On TCM Syndrome And Correlation Of Obstructive Sleep Apnea Hypopnea Syndrome And Chronic Obstructive Pulmonary Disease

Objective:Through the clinical observation of the patients with obstructive sleep apnea hypopnea syndrome（OASHS）and chronic obstructive pulmonary disease（COPD）,We will explore the relationship between the regularity of TCM syndromes and related indexes in OSAHS with COPD（Overlap Syndrome,OS）and enrich the connotation of modern syndrome differentiation of overlap syndrome and provide clinical basis for the prevention and treatment of traditional Chinese Medicine.Methods:From November 2017 to January 2020,the 156 patients with obstructive sleep apnea hypopnea syndrome and chronic obstructive pulmonary disease who were admitted to the Department of pulmonary disease and outpatient department of Qingdao Hiser medical center filled in the questionnaire of traditional Chinese medicine syndromes of OSAHS combined with COPD,the patients’data meeting the inclusion criteria were filled in the questionnaire and established the database by Excel,spss25.0 was used for statistics and descriptive statistics was used for the frequency and percentage of each variable.Through factor analysis and cluster analysis,the syndrome law of OSAHS combined with COPD was summarized.Result:1.Through the frequency analysis and factor analysis of the clinical symptoms and tongue pulse of the patients included,7 common factors were obtained,cluster analysis of common factors was carried out,and finally5 syndrome types were obtained:Spleen deficiency and dampness syndrome>Stagnant qi and blood stasis syndrome>lung and kidney deficiency syndrom>Stagnant qi and dampness syndrom>kidney yang deficiency syndrome.2.Patients with Overlap Syndrome were more male than female,and the majority of them were 50-59 years old and 60-69 years old.The proportion of patients with smoking and drinking was larger,and 78.2%of patients with BMI>24kg/m².3.There was no statistically significant with the degree of OSAHS（P>0.05）,and the syndrome type with the degree of COPD,age,BMI,ESS score and FEV₁as a percentage of the expected value were statistically significant（P<0.05）.Conclusion:1.According to the TCM syndrome types of Overlap Syndrome,the main causes are sputum dampness,blood stasis,qi stagnation,Qi deficiency and yang deficiency.The disease location is lung,spleen and kidney.In clinical treatment,we should consider the mixture of deficiency and excess,and use drugs accurately.2.The patients with overlap syndrome are mainly male elderly,In addition,smoking,rinking and obesity are the inducing factors of Overlap Syndrome.3.Through the correlation analysis,it is concluded that the patients with Spleen deficiency and dampness syndrome have obvious drowsiness and the patients with lung and kidney yang deficiency syndrome and kidney yang deficiency syndrome have poor pulmonary function.There was statistically significant with the degree of OSAHS and the degree of COPD.