Studyon Dffusion Ti Ensor Imagingin Patients With Cognitive Impairmentin Parkinson’s Dseasei

Purpose Toanalyzethecharacteristicsofmicrostructuralchangesinwhitematter subregionsinpatientswith Parkinson’sdiseaseandcognitiveimpairmentby diffusiontensorimaging(DTI).MethodsChoose72casesofpatientswith Parkinson’sdisease(PD)from Sptembere2017 to August2017inthe Frst Afiliated Hi f ospitalof Zhengzhou University nervoussubjectoutpatientandhospitalization astheresearchobject,the cognitivenormalgroup(PD-Cog NL)13cases,themildcognitiveimpairment group(PD-MCI)48casesanddementiagroup(PDD)11cases,anchoose54 casesofhealthyvolunteersascontrolgroup.Allsubjectssignedtheinformed consentbeforethestudy.Allsubjectswereevaluatedbyneuropsychological testscale:neuropsychiatricsymptomsquestionnaire(NPI)and Hamilton anxietyscale(HAMA)/depressionscale(HAMD)wereusedtoevaluate psychobehavioralsymptoms,andtheeffectsofdelusion,hallucination,severe anxiety/depressionandothermentalsymptomsontheenrolledstudywere excluded.Montrealcognitivefunctionassessmentscale(Mo CA)andsimple intelligencestatusscale(MMSE)wereusedtoevaluatetheircomprehensive cognitiveability.Dailyandsocialfunctioningwereassessedusingthedaily livingabilityscale(ADL).Microstructuralchangesin48 whitematter subregionsweremeasuredby DTI,andtheanisotropicfraction(FA)valuesof themeasuredsiteswererecorded.Kruskal-Wallisranksumtestwasusedfor differentcognitivedomainsineachsubgroupofpatientswith Parkinson’s disease.The34 brainfunctionpartitionswith statisticalsignificancewereselected,andthedifferentcognitivedomainsof PDpatientswerecomparedwiththewhitemattermicrostructuresby Spearmancorrelationanalysis.Results(1)Thedifferencesbetweenthe PD-Cog NLgroup,the PD-MCIgroup,the PDD groupandthecontrolgroupintheage,andeducationlevelwerestatistically significant(P<0.05),Therewasnosignificantdifferenceingender,duration,UPDRSscoreand HYclassification(P>0.05).-(2)Kruskal-Wallisranksumtestwasusedfordifferentcognitivedomainsin eachsubgroupof Parkinson’sdiseasepatients.PD-Cog NLgroup,PD-MCI groupand PDDgrouphadstatisticallysignificantdifferencesinvisualspace andexecutivefunction,attentionandcomputationalpower,languageability,abstractabilityanddelayedmemory(P<0.05),andtherewasnosignificant differenceinnomenclature(P>0.05).(3)Spearmancorrelationanalysiswasconductedtocomparedifferent cognitivedomainsandvariouswhitemattermicrostructuresinpatientswith Parkinson’sdisease.Theresultsshowedthat:a.Thevisualspaceandexecutivefunctionwerecorrelatedwiththeright uppercoronaradiata,therightposteriorcoronaradiataandtheleftstria terminalis,andwerepositivelycorrelated.Thecorrelationcoefficientswere0.266,0.315,0.243,P<0.05.b.Thenomenclaturewerecorrelatedwiththerightcingulategyrusandthe rightterminalstria,andwerepositivelycorrelated.Thecorrelationcoefficients were0.256,0.269,P<0.05.c.Theattentionandcomputationalabilitywerecorrelatedwiththe fornicolumn,therightposteriorcoronaradiata,therightanteriorcingulate gyrus,therightstriaterminalisandtheleftstriaterminalis,andwerepositively correlated.Thecorrelationcoefficientswere0.359,0.256,0.234,0.234,0.313,P<0.05.d.Thelanguageabilitywerecorrelatedwiththerightposteriorcoronaradiata andleftstriaterminalis,andwerepositivelycorrelated.Thecorrelation coefficientswere0.247,0.297,P<0.05.e.Theabstractabilitywerecorrelatedwiththefornicolumn,theleftinternal capsuleforelimbandtheleftstriaterminalis,andwerepositivelycorrelated.Thecorrelationcoefficientswere0.381,0.245,0.245,P<0.05.f.Thedelayedmemorywascorrelatedwiththerightposteriorcoronaradiata,anditwaspositivelycorrelated.Thecorrelationcoefficientwas0.267,P<0.05.g.Theorientationwerecorrelatedwithleftcerebralpeduncle,rightinternal capsuleforelimb,leftinternalcapsuleforelimb,rightposteriorcoronaradiata,leftposteriorcoronaradiata,leftposteriorthalamicradiatio,rightcapsula externa,leftcapsulaexterna,therightcingulategyrus,therightstria terminalisandtheleftuncinatefascicle,andtheywerepositivelycorrelated.Thecorrelationcoefficientswere0.241,0.301,0.282,0.346,0.263,0.288,0.279,0.323,0.263,0.240,0.299.P<0.05.Conclusion1.Thecognitivedysfunctionof Parkinson’sdiseaseisnotrelatedtogender,severityofillness,andcourseofdisease,andisrelatedtoageandeducation level.2.Cognitivedysfunctionof Parkinson’sdiseaseinvolvesmultiplecognitive domains,includingvisualspaceandexecutivefunction,attentionand computationalpower,languageability,abstractability,delayedmemory,orientation.3.Thecognitivedysfunctionof Parkinson’sdiseaseisrelatedtothechanges ofmultiplewhitemattermicrostructure,includingthecoronaradiata,thestria terminalis,thecingulategyrus,thefornix,theinternalcapsule,thecerebral peduncle,theposteriorthalamicradiation,thecapsulaexternaandthe uncinatefascicle.