Lipoprotein(A)as A Predictor For The Presence And Severity Of Premature Coronary Artery Disease:an Across-sectional Analysis

Background:The incidence trend of CAD has been presenting a younger characteristic.Unfortunately,the causes for the patients with PCAD is not fully understood currently.Plasma Lp(a)level has been reported to be associated with cardiovascular risk in many studies.This study aimed to examine the association between plasma Lp(a)concentration and PCAD.Methods:A total of 2433 individuals(male<55 years old,female<65 years old)who underwent CAG from March 2016 to February 2019 were included in this study and were divided into PCAD group(n=1751)and non-CAD group(n=682).According to the results of angiography,their clinical and laboratory parameters were collected and serum Lp(a)level was detected by immunoturbidimetry.The severity of CAD was evaluated using Gensini score and divided into three subgroups.The relationship between serum Lp(a)levels and the presence and severity of PCAD was analyzed respectively.Serum Lp(a)and GS are continuous variables of skew distribution.So when we do regression analysis,we transformed it to logarithm.Results:The level of serum Lp(a)in PCAD group was significantly higher than that in non-CAD group(p<0.001).The serum Lp(a)concentration in the highest GS group was significantly higher than that in the lowest GS group(p<0.001).In multivariate logistic regression analysis,elevated serum Lp(a)levels were independently associated with PCAD(OR=3.10,p<0.001).Multivariate linear regression analysis showed that elevated serum Lp(a)levels were correlated with higher GS(b=0.41,p<0.001).Conclusions:The Cross-sectional study suggested that Lp(a)concentration was correlated with the presence and severity of PCAD.The results should be confirmed by larger prospective studies.