| ObjectiveTo identify the changes of axial length,choroidal thickness and visual function of school-age children during the course of myopia progression.MethodsIn this study,86 children aged 7 to 15 years old with myopia were analyzed from December 2020 to February 2021 in the ophthalmology clinic of Shandong Provincial Hospital.After inquiring medical history and taking basic examinations,the samples matching the requirements were included.Myopia diopters visual function was examined by the comprehensive optometry,including distant/near level phoria,AC/A value,positive relative accommodation,negative relative accommodation,accommodative response,convergence near point,accomodative amplitude,accomodative sensitivity,etc.The length of the axis of the eye was measured with IOL Master and the choroid thickness was measured with OCTA(Optical Coherence Tomography Angiography).The patients were divided into three groups according to myopia diopters,including low myopia group(<-3.0D),moderate myopia group(ranging from-6.0D to-3.0D)and high myopia group(≥-6.0D).SPSS-25 software was used for statistical analysis of the results.Multiple linear regression analysis was used for the measurement data,and χ2 test was used for the counting data.Changes in the parameters of axial length,choroid thickness and visual function of school-age children at different myopia levels and different age stages were analyzed.Results1.Axial length was positively correlated with equivalent spherical lens with a correlation coefficient of 0.341(P<0.05).There was no significance between axial length and age(P>0.05).2.There was a negative correlation between choroid thickness and spherical equivalent,and the correlation coefficient was-8.836,which was statistically significant(P<0.05).There was no statistically significant correlation between choroid thickness and age(P>0.05).3.There was no statistical significance in the correlation analysis between distant/near level phoria,spherical equivalent and age(P>0.05).In different groups,with the myopia diopters increasing,the proportion of exophoria was higher while the proportion of esophoria(P<0.05).4.Correlation analysis between AC/A and spherical equivalent and age showed no statistical significance(P>0.05).There was no statistical significance in AC/A among different myopia degree groups(P>0.05).5.Correlation analysis between positive/negative relative accommodation and spherical equivalent and age showed no statistical significance(P>0.05).There was no statistical significance between positive/negative relative accommodation and myopia diopters among all groups(P>0.05).6.There was no statistical significance between the accommodation response and spherical equivalent(P>0.05).However,the accommodation response was negatively correlated with age(P<0.05)and there was no statistical significance between the accommodation response and different myopia diopter groups(P>0.05).7.There was no statistical significance in the correlation analysis among the convergence near point,spherical equivalent and age(P>0.05).There was no statistical significance in the difference of the convergence near point between the groups with different myopia diopters(P>0.05).8.The correlation analysis between binocular accommodation amplitude and spherical equivalent showed no statistical significance(P>0.05).The former was negatively correlated with age(P<0.05),and the difference of binocular accommodation amplitude among different myopia levels was not statistically significant(P>0.05).There was no statistical significance in the correlation analysis between the amplitude of monocular accommodation and the spherical equivalent(P>0.05),but the former was negatively correlated with age(P<0.05).There was no statistical significant difference between amplitude of monocular accommodation among groups with different myopia degrees(P>0.05).9.There was no statistical significance in the correlation analysis of accommodation flexibility with spherical equivalent and age(P>0.05),and there was no statistical significance between accommodation flexibility among different myopia diopters(P>0.05).ConclusionWith the continuous increase of myopia diopters,the axial length keeps growing and the choroid thickness keeps thinning during the genesis and development of myopia in school-age children.Meanwhile,the regulatory response and range decreased with age.There was no significant correlation between the diopters of myopia and distant/near level phoria,AC/A,positive/negative relative accormmodation,accormmodative response,convergence near point,range of accormmodation and flexibility of accormmodation.Abnormal visual function exists in each stage of myopia,and there is no obvious difference.We speculate that the abnormal visual function may occur before myopia and continue during the whole process of myopia. |
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