Study On Risk Factors Of Serum Magnesium And Abdominal Aortic Calcification In Non-dialysis Patients With Chronic Kidney Disease 3-5 And Analysis Of TCM Syndromes

Objective:The purpose of this paper is to research on chronic kidney disease(CKD)3-5 for non dialysis patients blood magnesium and abdominal aortic calcification and the relationship between TCM syndrome,chronic kidney disease(CKD)3-5 period of dialysis patients with abdominal aortic calcification associated risk factors and the analysis of syndromes,in order to merge of vascular calcification period and provides new train of thought of syndrome differentiation of traditional Chinese medicine treatment for patients with chronic kidney disease(CKD).Methods:A cross-sectional study was conducted to select 98 patients with chronic kidney disease stage 3-5 and non-dialysis patients who met the standards of inpatient and inpatient follow-up in the Department of Nephrology of Hubei Hospital of Traditional Chinese Medicine from June 2019 to June 2020.The general data of the patients were collected.Including gender,age,height,weight,blood pressure,blood lipid,blood glucose,basic diseases,past medical history,TCM syndromes and related laboratory examination indexes.The patients were divided into the abdominal aortic calcification group and the non-abdominal aortic calcification group by plain scanning of abdominal X-ray film.The basic information,experimental data and TCM syndromes of the two groups of patients were collected and analyzed.Logistic regression analysis was used to explore the risk factors related to abdominal aortic calcification.Conclusions:(1)There were no statistical differences in gender,age and CKD stage among enrolled patients.(2)By comparing the basic information of patients in the calcification group and the non-calcification group,there was no statistical significance between the two groups in terms of gender,history of alcohol consumption,CKD stage,BMI,basic diseases,etc.,but there was statistical significance between the two groups in terms of age and smoking history(P<0.05).(3)The laboratory biochemical indexes of the calcified group and the non-calcified group were compared,and it was found that the serum albumin,serum phosphorus,calcium-phosphorus product,serum magnesium,LDL-C and other aspects of the calcified group were statistically significant(P<0.05).(4)It was found by examination that the number of patients with the syndrome of spleen and kidney qi deficiency and blood stasis and turbidity in the calcification group was significantly higher than that in the non-calcification group,and the non-calcification group mainly presented the syndrome of spleen and kidney Yang deficiency and water dampness,with statistical significance(P<0.05).(5)The above age,serum alb,serum phosphorus,serum magnesium,LDL-C,spleen-kidney qi deficiency syndrome,spleen-kidney Yang deficiency syndrome,blood stasis and turbidity,water dampness syndrome and damp-heat syndrome were taken as independent variables,and abdominal aortic calcification was taken as dependent variable(AAC=1,no AAC=0),and multivariate logistic regression analysis was conducted.The results showed that age,blood phosphorus,LDL-C,spleen-kidney Yang deficiency syndrome,damp-heat syndrome(OR>1)were the risk factors for promoting vascular calcification.Serum albumin,serum magnesium,syndrome of spleen and kidney qi deficiency,syndrome of blood stasis and turbidity,and syndrome of water dampness(OR<1)were the protective factors of vascular calcification.