| Objective:To observe the clinical efficacy and safety of fire acupuncture in the treatment of alopecia areata(AA).The change of final hair density detected by dermatoscope was taken as the observation index.The level of 25 hydroxyvitamin D(25(OH)D)in patients with AA before and after treatment was observed,so as to provide clinical basis for the promotion of fire acupuncture in the treatment of AA and analyze the correlation between alopecia areata and vitamin D.Method:First,61 patients with alopecia areata that meet the criteria were collected.According to the principle of randomization,the patients were divided into treatment group and control group,with31 cases in the treatment group and 30 cases in the control group.The treatment group was treated with fire-needle and calcipotriol ointment for external use,and the control group was only treated with calcipotriol ointment.The level of 25(OH)D and the final hair density of the patients were collected before and after 12 weeks of treatment.The treatment effect Score was evaluated by the Dermatological Quality of Life Score(DLQI)and Alopecia Symptom Score,and the relevant data was statistically analyzed by SPSS22.0.Result:1.Observed by naked eyes,as the treatment progresses,the terminal hair density of the two groups increased progressively,and the drugs used in the treatment group and the control group had therapeutic effects on alopecia areata.After 12 weeks of treatment,9 cases in the treatment group were cured,13 cases had significant effects,6 cases were effective,2 cases were ineffective,and 1case was allergic.The total effective rate reached 93.33%.While in the control group,only 5 cases were cured,and 7 cases had significant effects,10 cases were effective,8 cases were ineffective,and the total effective rate was only 73.33%.The difference in clinical efficacy between the two groups(P<0.05)indicated that the total effective rate of the treatment group was significantly higher than that of the control group.2.Before treatment,there was no statistical difference in the scores of alopecia symptoms between the treatment group and the control group(P>0.05).After 12 weeks of treatment,the alopecia symptoms scores of each group before and after treatment were statistically different(P<0.05),and the scores between the two groups were also statistically different(P<0.05).3.According to microscopic observation by dermoscopy,there was no statistical difference in terminal hair density between the treatment group and the control group before treatment(P>0.05).After 12 weeks of treatment,the terminal hair density of each group before and after treatment was statistically different(P<0.05),indicating that the two treatment options had a certain effect.Moreover,the terminal hair density between the two groups was also statistically different(P<0.05),indicating that the effect of the treatment group was better than that of the control group.4.Before the treatment,there was no statistical difference in 25(OH)D between the treatment group and the control group(P>0.05).After 12 weeks of treatment,25(OH)D of each group before and after treatment were statistically different(P<0.05),and25(OH)D between the two groups was also statistically different(P<0.05),Which showed that after treatment,the 25(OH)D of the two groups had been improved,and the effect of the treatment group was more obvious.5.After linear regression analysis,there was no significant correlation between the scores of alopecia areata and 25(OH)D(P>0.05).6.There was 1 case of allergies in the treatment group,but not in the control group.There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:1.External application of calcipotriol ointment alone and fire needle combined with external application of calcipotriol ointment both had certain clinical effects in the treatment of alopecia areata,but the combination of fire needling had a more significant effect and better safety.2.After 12 weeks of treatment,the scores of alopecia symptoms in the treatment group and the control group were improved,and the improvement in the treatment group was more obvious.3.Both therapies could improve the patient’s 25(OH)D level,but the combined fire acupuncture improves more significantly.And the level of 25(OH)D might not be the main factor in determining the severity of alopecia areata.4.Non-invasive dermoscopy could help the diagnosis of alopecia areata,and could make objective judgments on the therapeutic effect of alopecia areata,which is worthy of clinical application. |
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