Clinical Observation Of Honghua Jixueteng Decoction Combined With Calcipotriol Betamethasone Ointment In The Treatment Of Psoriasis

Objective: To observe the clinical efficacy,safety and recurrence of Honghua jixueteng decoction combined with calcipotriol betamethasone ointment in the treatment of psoriasis vulgaris blood stasis syndrome,and to provide an effective plan for the treatment of psoriasis vulgaris blood stasis syndrome.Methods: From July 2019 to January 2020,84 patients who met the criteria for diagnosis and inclusion of psoriasis vulgaris blood stasis syndrome were randomly divided into treatment group and control group,with 42 cases in each group.Due to the elimination and shedding test patients,the final two groups actually completed the test with 39 cases in each group.The treatment group was treated with Honghua jixueteng decoction,while the control group was treated with Taohong Siwu Decoction.In order to ensure the efficacy,all the decoction were given by the traditional Chinese medicine dispensary of Hubei Provincial Hospital of TCM.The patients were advised to take it half an hour after breakfast and dinner,twice a day,1 bag / time,and both groups were thin coated with calcipotriol betamethasone ointment before sleep.All courses of treatment were 10 weeks.The area and severity(PASI)score and pruritus degree score of the patients were recorded before treatment,after 5 weeks treatment and after 10 weeks treatment respectively.The occurrence of adverse reactions during the trial was observed and counted,and the clinical efficacy and safety of the treatment group and the control group were evaluated.After the end of the trial course,the two groups of clinical recovery and effective patients were followed up for 3 months to understand the recurrence.All the clinical observation data collected were input into the computer,and then the Chinese version of spss25.0 software was used for statistical analysis.Results:1.In this clinical observation,84 patients were included in the original plan.Finally,78 patients actually completed the trial,5 patients were excluded,and 1 patient fell off.2.Before treatment,there was no significant difference in the gender,age,course of disease,PASI score and pruritus degree score between the two groups(P > 0.05).3.After 5 weeks of treatment,the PASI scores of the treatment group and the control group decreased significantly compared with those before treatment,P < 0.05,the difference was statistically significant;the score of pruritus degree in the treatment group was significantly improved than before treatment,P < 0.05,the difference was statistically significant;the score of pruritus degree in the control group was not significantly lower than that before treatment,P > 0.05,and the difference was not statistically significant;The PASI score and pruritus degree score between the treatment group and the control group were not statistically significant,P > 0.05,indicating that the improvement of PASI score and pruritus degree score were similar between the two groups.4.After 10 weeks of treatment,the PASI score and pruritus degree score of the treatment group and the control group decreased significantly compared with those before treatment,P < 0.05,the difference was statistically significant;and the difference was statistically significant,which showed that the improvement of PASI score and pruritus degree score in the treatment group was significantly better than that of the control group,P < 0.05;the improvement degree of PASI score was used as the criterion of clinical efficacy and the total effective rates of the treatment group and the control group were 92.31% and 71.79%,respectively.After chi square test,P < 0.05,the difference was statistically significant,indicating that the clinical effect of the treatment group was significantly higher than that of the control group.5.Before and after treatment,the three routine examinations,ECG,liver and kidney function of the two groups did not show obvious abnormality;during the treatment,no obvious adverse reactions were found in both groups.Only 2 patients in the treatment group showed mild stomach discomfort and nausea and vomiting,and 3patients in the control group showed mild diarrhea,and the symptoms were relieved after corresponding treatment.6.After 3 months follow-up,3 cases of relapse in the treatment group and 8 cases in the control group were relapsed.The difference was statistically significant after chi square test,P < 0.05,indicating that the recurrence of the treatment group was better than that of the control group.Conclusion: The combination of Honghua jixueteng decoction and calcipotriol betamethasone ointment is effective in the treatment of psoriasis vulgaris blood stasis syndrome,with less adverse reactions and low recurrence rate,which is worth popularizing and applying in clinic.