| PurposeThe sST2 and thyroid hormone(FT4,FT3,TSH)levels of elderly patients with chronic ejection fraction decreased heart failure were determined to determine the value of the above two indexes in optimizing cardiac function classification and predicting prognosis of elderly patients with chronic heart failure.Thus,the risk stratification of the patient’s heart function can be carried out early to judge the prognosis.MethodsOn a fully informed basis,Get the patient,The consent of the family and the relevant departments,From August 2019 to August 2020,he was admitted to the Department of dry diagnosis and Cardiology of the second affiliated Hospital of Shenyang Medical College,And diagnosed with chronic low ejection fraction(EF<40%)heart failure,The general clinical characteristics of the eligible patients(135)were registered,Including gender,Age,Admission diagnosis,Height,Weight,Blood pressure,Heart rate,Native,Contact information,etc;Ask about smoking,drinking and drinking habits,family history,hypertension,diabetes,dyslipidemia,abnormal blood sugar,Stroke,Previous cardiovascular disease,History of diabetes and hypertension.Improve blood routine,coagulation function analysis,biochemical indicators,cardiotin,echocardiography and other examinations.For patients with heart failure,thyroid hormone and SST2,According to age,90 cases were divided into elderly group(age60-85 years),And non-aged group(control group age 18-60 years old)45 cases;The elderly group was divided into 18 cases of cardiac function II grade according to NYHA cardiac function,Cardiac function III grade 31,Cardiac function IV grade 41 cases.SPSS23.0 statistics software was used for data analysis.Measurement data are expressed as mean ± standard deviation(x±s),Compare the tests,Single factor ANOVA was used to compare the mean values between groups;Correlation is analyzed by spearman grade correlation.The count is expressed as a percentage,Compare the use ofχ2 inspection.For non-normal distribution,median M and range are used,The rank sum test was used in the comparison between groups;And using the subject’s work characteristics(ROC)curve,Evaluation sst2,The value of thyroid hormone in the diagnosis of cardiac function,p<0.05 difference was statistically significant.Results1.Comparison of general clinical data between aged and non-aged groups:There were significant differences in sex,TC,LDL-C,HDL-C,NT-pro BNP,fasting blood glucose,creatinine,diabetes history(p<0.05),There was no significant difference in TG,smoking history and hypertension history(p>0.05)2.Comparison of general clinical data among patients with different cardiac function classification in elderly group:The history of creatinine and HDL-C,NT-pro BNP,hypertension was significantly different(p<0.05);There was no significant difference in sex,TG,TC,LDL-C,blood glucose,diabetes history and smoking history(p>0.05)3.Comparison of elderly and non-aged groups:sst2 level increased and FT4 level decreased(p<0.05)4.Comparison between patients with different cardiac function grades in the elderly group:The serum sst2 level increased gradually and the FT3 level decreased gradually according to cardiac function II,III and IV levels(p<0.05)5.As can be seen from the correlation analysis table:There was no significant correlation between serum ssst2 and thyroid hormone in elderly patients with chronic heart failure(p>0.05),There was no significant correlation between sst2 and NT-pro BNP(p>0.05).6.A working characteristics(ROC)curve of the subjects shows:The effect of serum sst2 on the diagnosis of cardiac function(AUC:0.739,95%CI :0.648-0.827,P=0.000),The product under the curve of FT4,FT3 and TSH is less than0.7,Serum sst2 has certain value in the diagnosis of cardiac function in elderly patients with chronic ejection fraction decreased heart failure.Conclusion1.serum sst2,FT4 was significantly different in different age groups.2.Serum sst2 and FT3 can reflect the severity of chronic heart failure in the elderly.3.Serum sst2 can be used to diagnose cardiac function in elderly patients with chronic ejection fraction decreased heart failure,and its prognosis is of certain value. |
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