The Effect Of The Mean Platelet Volume/Platelet Count Ratio On The Clinical Outcome Of Coronary Artery Disease After PCI

Objective:To determine whether the MPV/PC ratio on admission has any predictive value for long-term prognosis in patients with coronary artery disease who underwent percutaneous coronary intervention(PCI).Methods: A retrospective cohort study was conducted.The clinical data of 6046 patients after PCI who admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2008 to December 2016 were collected.Follow-up endpoints were : all cause mortality(ACM),cardiac mortality(CM),bleeding events and major adverse cardiovascular events(MACE).Receiver operating characteristic(ROC)curve analyses were used to determine the optimal MPV/PC ratio for grouping.Multi-factor Cox regression analysis was used to compare the correlation between different groups and long-term prognosis.Results: The high MPV/PC group had higher ACM [132(6.4%)vs.177(4.5%)],CM [115(5.6%)vs.136(3.4%),and MACE [327(15.8%)vs.458(11.5%)].Multivariate COX regression analysis showed that compared with the low MPV/PC ratio group,the risk of all-cause death in the high-value group was increased by 46.6%(HR=1.466,95%CI: 1.159-1.852,P=0.001),cardiac death increased by 64.7%(HR=1.647 95%CI: 1.271-2.137,P<0.001);the incidence of MACE increased by 31.8%(HR= 1.318,95%CI: 1.138-1.527,P<0.001).Conclusion: Higher MPV/PC ratio is associated with poor prognosis after PCI.It can be an independent risk factor for poor prognosis.