Effect Of Repetitive Transcranial Magnetic Stimulation On Patients With Parkinson’s Disease

Objective: To investigate whether high-frequency repetitively transcranial magn-etic stimulation(r TMS)in the left dorsolateral prefrontal cortex(DLPFC)can imp-rove motor symptoms and sleep disorders in patients with Parkinson’s disease(PD).Methods: The Unified Parkinson’s Disease Rating Scale Part III(UPDRS-Ⅲ)and t-he Timed Up and Go test(TUG)and Pittsburgh Sleep Quality Index(PSQI)were used to evaluate thirty-four patients patients who received r TMS under standard practice for 10 consecutive days(the treatment group)and forty-two patients who maintained their oral medication regimens and did not receive r TMS(the control group).The improvement of motor symptoms and sleep disorders in two groups at baseline(stage T0),at the end of treatment(stage T1),and 1 month after the end of treatment(stage T2)were compared and analyzed.Results: All participants completed the study and no serious adverse events were reported.There was no stati-stical significance in age,gender,severity of disease,cognitive ability and medication situation between 2 groups(P>0.05).In T0 stage,There were no significant d-ifferences between the treatment group and the control group in UPDRS-Ⅲ total s-core,TUG time and PSQI score(P>0.05).In T1 stage,the total score of UPDRS-Ⅲ,TUG time and PSQI score in the treatment group were lower than those in th-e control group,and the difference was statistically significant(P<0.05).The totals core of UPDRS-Ⅲ,TUG time and PSQI in the treatment group were lower than t-hose in the control group at T2 stage,and the difference was statistically significant(P<0.05).In the comparison of the treatment group before and after treatment,the total score of UPDRS-Ⅲ,TUG time and PSQI score at T1 and T2 were lower than those at T0,the difference was statistically significant(P<0.05).However,when the statistical analysis at T1 and T2 was conducted,there was no statistically significant difference in the total score of each scale between the two groups(P>0.05).Conclusion: On the basis of conventional drug therapy,supplemented with regular r TMS treatment in the left DLPFC area,the improvement of sleep disturbance and motor symptoms in PD patients can be observed,which is better than the simple drug treatment,and the effect can be maintained for at least 1 month.