| Objective: To study the clinical characteristics and related risk factors of calcific valvular heart disease in elderly hospitalized patients,and to provide a basis for finding controllable factors,so as to delay the progression of the disease and improve the long-term prognosis of patients.Methods: Selected patients who were hospitalized in the First Affiliated Hospital of Xinjiang Medical University from October 2018 to July 2020,aged≥60 years old,and underwent echocardiography,carotid ultrasound and other examinations.A total of 759 cases(male 400 cases,female 359 cases)were the research objects.According to the diagnostic criteria of calcified valvular heart disease,they were divided into calcified valve group and non-calcified valve group(control group),of which257 cases were in the calcified valve group and 502 cases were in the control group.Collect the patient’s age,gender,smoking history,chronic disease history,test results and other clinical data,summarize the clinical features of calcific valvular heart disease,analyze the risk factors,and draw the ROC curve reflecting the value of independent risk factors in the diagnosis of heart valve calcification.Results: 1.Among patients with senile calcific valvular heart disease,simple aortic valve calcification was the most common(50.6%),followed by aortic valve and mitral valve calcification involving both(31.1%),and again for simple mitral valve Calcification(18.3%).Simple aortic valve calcification was more common in men than women(P<0.001).Simple mitral valve calcification,aortic valve calcification and mitral valve calcification were more common in women than men(P=0.039,P=0.008).Mitral valve calcification with mitral regurgitation was more common in women than in men(P=0.025).Among elderly patients with calcific valvular heart disease,there was no difference in calcified valve structure between Han and Uygur nationalities(P>0.05).There were statistically significant differences in aortic valve and mitral valve calcification in different age groups(P=0.023).2.Calcified valve group and control group in age,history of hypertension,ethnicity,carotid atherosclerosis,Hcy,Lp(a),TG,HDL,APOB,T3,FT3,Anti-TG,blood phosphorus,calcium to phosphorus ratio There were statistically significant differences in lymphocytes,granular-to-leaching ratio,PLT and PDW(P<0.05).Multivariate logistic regression analysis show that age,Hcy,Lp(a),PDW,and carotid atherosclerosis are independent risk factors for elderly hospitalized patients with calcific valvular heart disease(P<0.05).3.The ROC curve results show that: age,Hcy,Lp(a),PDW are statistically significant differences between the calcified valve group and the control group(P<0.05),and the AUC area of age,Hcy,Lp(a),PDW They are: 0.784,0.619,0.584,0.629.Conclusion: 1.Among elderly hospitalized patients with calcific valvular heart disease,simple aortic valve calcification is the most common,followed by both aortic valve and mitral valve involvement,and again pure mitral valve calcification.Simple aortic valve calcification is more common in men,and simple mitral valve calcification,aortic valve calcification combined with mitral valve calcification are more common in women.2.Age is an independent risk factor for calcified valvular heart disease in elderly hospitalized patients.With age,the prevalence of calcified valvular heart disease increases significantly,and combined valve calcification is prone to occur.3.In addition to age,Hcy,Lp(a),PDW,and carotid atherosclerosis are independent risk factors for calcific valvular heart disease... |
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