Significance Of Platelet Count And Serum VEGF Expression In Ulcerative Colitis

Objective: To detect the correlation between platelet count and Vascular endothelial growth factor(VEGF)expression in patients with ulcerative colitis(UC)and its clinical significance.Methods:Methods: 82 patients with UC were selected as the research objects.The serum VEGF concentration was measured by enzyme-linked immunosorbent assay(ELISA).The subjects were divided into two groups: non platelet count group(group A)and platelet count group(group B).The patients were divided into mild group(Group C),moderate group(Group D),severe group(Group E),sufficient vitamin D group(Group F),insufficient vitamin D group(group G),and 40 patients with simple gastric and intestinal polyps as control group.The correlation between platelet count and VEGF and the degree of disease course were analyzed.The correlation between vitamin D level,interleukin-6 and platelet count,VEGF were analyzed.Results:Compared with the control group,the concentration of VEGF in group A and group B was the highest,followed by that in the non platelet elevated group,and the lowest in the control group.In group C,D,e and control group,the difference of platelet count in Group E was the largest,followed by Group D.there was no significant difference between control group and group C.The concentration of VEGF was in the order of E group,D group and C group.Compared with group F,platelet count and serum VEGF concentration in group G were significantly higher than those in group F.Conclusion: The level of vitamin D can affect the platelet count and serum VEGF concentration.IL-6 is positively correlated with platelet count and serum VEGF concentration.