Feasibility Analysis Of Modified Sentinel Lymph Node Biopsy For Acral Malignant Melanoma

Objective : To explore the application analysis of modified sentinel lymph node biopsy for acral malignant melanoma.Methods:From January 2017 to January 2020,60 patients with acral malignant melanoma were selected from the Department of bone and soft tissue,Affiliated Tumor Hospital of Xinjiang Medical University.The patients in the observation group were examined by ultrasound combined with methylene blue to detect sentinel lymph nodes around the wrist or ankle joint.The sentinel lymph nodes in the control group were detected by methylene blue around peritumoral injection.The patients were followed up regularly to evaluate the postoperative effect.The detection number,detection rate,sensitivity,false negative rate and the size of SLN were compared between the two groups.Results:There was no significant difference in gender,age,ulcer,site,thickness,operation between the two groups by chi-square test.In the observation group,the detection rate of SLN was 100%(30/30),the sensitivity was 87.5%(7/8),and the false negative rate was 3.3%(1/30).In the control group,the detection rate of SLN was 83.3%(25/30),the sensitivity was 62.5%(5/8),and the false negative rate was 12%(3/25).By Fisher test,all P < 0.05,the difference was statistically significant.The average number of SLN detected in the observation group(3.54±1.22)was significantly more than that in the control group(2.03±1.14),and the difference was statistically significant(t=7.121,P<0.05).The minimum length of SLN in the observation group was 1.5mm,and that in the control group was 10 mm.The average minimum length of SLN in the observation group was 5.37 mm,the standard deviation was 2.16 mm,and the average minimum length of SLN in the control group was 11.83 mm,the standard deviation was 5.37 mm,the difference was statistically significant(t=6.353,P<0.05).Conclusions Compared with the method of peritumoral injection,the modified sentinel lymph node biopsy has higher application value and higher accuracy in the detection of acral SLN.