| Objective: To investigate the comparison of High-flow nasal cannula(HFNC)and Noninvasive positive pressure ventilation(NIPPV)in patients with acute exacerbations of chronic obstructive pulmonary disease(AECOPD)after early removal of the tracheal intubation.Methods: From January 2019 to September 2020,among the AECOPD patients admitted to the Respiratory intensive care unit(RICU)of the First Affiliated Hospital of Xinjiang Medical University,the patients who were given mechanical ventilation for endotracheal intubation were used as the research objects.The tracheal intubation was removed during the "pulmonary infection control window"(PIC window),and then randomly divided into two groups.One group was given HFNC treatment,which was the HFNC group,and the other group was given NIPPV treatment,which was the NIPPV group.The incidence of reintubation events within 7 days after extubation was compared between the two groups,and the incidence of complications(compression,bloating,aspiration,delirium,etc.),mortality,RICU hospital stay and total hospital stay were compared between the two groups.Results:44 patients were included in the study,of which 20 were in the HFNC group and 24 were in the NIPPV group.The rate of reintubation within 7 days in the HFNC group was significantly higher than that in the NIPPV group [35%(7/20)VS 4.16 %(1/24),P<0.05];however,the complication during treatment in the HFNC group was significantly lower than that in the NIPPV group [(0 VS25%(6/24),P<0.05)];Compared with the NIPPV group,there was no significant difference in mortality in the HFNC group[(5%(1/20)VS 4.2%(1/24),P>0.05)].There were no significant differences in RICU hospital stay and total hospital stay(day:19.45±10.81VS15.54±7.21,27.35±12.21 VS 23.33±10.87,all P>0.05).Conclusion:Sequential HFNC after early extubation in AECOPD patients has a significantly higher reintubation rate within 7days than NIPPV,but the patient’s comfort is higher and complications are significantly reduced. |
PDF Full Text Request