Effect Of Timing Of Fluid Resuscitation On Prognosis In Patients With Sepsis Associated Acute Kidney Injury

Objective:To investigate the effect of fluid resuscitation timing on the prognosis of patients with sepsis-related acute kidney injury.Methods:The study used retrospective research methods to collect Patients with sepsis-related acute kidney injury admitted to the Department of Critical Care Medicine,People’s Hospital of Xinjiang Uygur Autonomous Region from September 2016 to September 2019.According to the fluid resuscitation time,the patients were divided into two groups,namely the early group(<6 hours)and late group(>6 hours).Collect patient’s general information,infection site,Acute Physiology and Chronic Health assessment score,Sequential Organ Failure Assessment score within 24 hours of admission to the ICU,Observe the serum creatinine(Scr),urine output,APACHE Ⅱ score during hospitalization,renal replacement therapy(RRT)usage,stay in ICU,and survival status when leaving ICU.Results:In the end,A total of 80 patients were included,early recovery and delayed resuscitation group 40 cases,The two groups of patients had no statistical difference in gender,age,previous medical history,source of infection,APACHE Ⅱ score and SOFA score within 24 hours after entering the ICU(P>0.05),and they were comparable.The changes in creatinine values of the two groups of patients from the first day to the time of leaving the ICU showed a gradual downward trend,and the differences between the groups were statistically significant(P<0.05);Urine volume at 6 hours,12 hours and 24 hours after fluid treatment was slightly higher in the early group than in the delayed group,and there was a statistical difference between the two groups(P<0.05);Patients in both groups showed a slight downward trend in APACHEⅡ scores when they entered the ICU to exit the ICU,and there was a statistical difference between the two groups(P<0.05);the use of RRT in the two groups,Survival status at the time of leaving the ICU,There was no significant difference between the two groups(P>0.05);Two groups of patients in the ICU comparison,the difference was statistically significant(P<0.05).Conclusion:In patients with sepsis-related acute kidney injury,early fluid resuscitation may have better renal protection,slow down the condition,and shorten the length of ICU stay.