A Study Of Risk Factors For Spontaneous Bacterial Peritonitis In Patients With Ascites In Cirrhosis

Objective: To study the risk factors of spontaneous bacterial peritonitis(SBP)in patients with liver cirrhosis with ascites,and to provide reliable clinical evidence for the early diagnosis and treatment of SBP.Methods: A collection of 206 patients with cirrhosis and ascites who were diagnosed with liver cirrhosis and ascites in the Department of Gastroenterology and Infectious Diseases of the Second Affiliated Hospital of Xinjiang Medical University from January,2013 to December,2019 were collected.Livers were selected based on the results of ascites culture during hospitalization.There were 100 patients with cirrhosis complicated by SBP(SBP group),and 106 patients with cirrhosis and ascites without SBP(control group).The biochemical indicators and general data characteristics at admission were compared between the two groups,and the factors that may affect the occurrence of SBP were singled Factor analysis and multi-factor Logistic regression model analysis.Results: Univariate analysis showed that Hepatic encephalopathy,history of gastrointestinal bleeding,internal diameter of the main portal vein,serum total bilirubin level,platelet count,D-dimer,prothrombin time and Child-Pugh score showed statistically significant differences between the two groups.(P<0.05).Multivariate Logistic regression analysis showed that Child-Pugh grade C,increased portal trunk diameter level(≥13mm),increased D-dimer level(≥500ug/L)were independent risk factors for SBP(P<0.05).Conclusions: Liver function,Child-Pugh grade C,portal main diameter widened,and D-dimer level increased may be independent risk factors for SBP in patients with cirrhosis ascites.and the occurrence of SBP in patients with ascites should be guarded when these high risk factors are present.