| The paper consists of three parts: the first part is summary;the second part is the theoretical discussion of Feiteng eight methods;the third part is clinical trial research(Randomized Controlled Trial,RCT).The review part discusses the etiology,pathogenesis,acupuncture and traditional Chinese and western medicine treatment of post-stroke depression(Post-strokedepression,PSD).The theoretical discussion part discusses the origin,time opening method,application and prospect of Feiteng eight methods.In the part of clinical trial,we observed the efficacy and safety of Feiteng eight methods in the treatment of PSD,and discussed the related mechanism of Feiteng eight methods in the treatment of PSD.Research background:Post-stroke depression(PSD),also known as post-stroke depression,belongs to secondary depression.It is ubiquitous after stroke,which can occur at all stages after stroke,and has become the focus of global public health attention.At present,the etiology and pathogenesis of PSD are still unclear.Therefore,the pathological mechanism and treatment of post-stroke depression need new research and exploration.A large number of studies have shown that traditional Chinese medicine and acupuncture are effective in the treatment of PSD.In the early stage,the tutor used Feiteng eight methods to treat PSD and achieved a good effect,but did not carry out a strict RCT test.Based on the above background,through the rigorous design of the RCT trial,this study observed the clinical efficacy and safety of Feiteng eight methods in patients with post-stroke depression,and discussed its therapeutic mechanism.Research objective:To explore the clinical efficacy,safety and mechanism of Feiteng eight methods in the treatment of PSD,and to reveal some of the molecular mechanisms of this therapy in the treatment of PSD,so as to provide objective basis for the study of the effect mechanism and clinical application of Feiteng eight methods in the treatment of PSD.Methods:This study adopts a single-blind,randomized controlled clinical trial design.In the future,patients from the third affiliated Hospital of Yunnan University of traditional Chinese Medicine will be included in 70 patients with PSD according to the enrollment criteria.The patients who meet the criteria were randomly divided into two groups: the treatment group(n=36)and the control group(n=34).The treatment group was treated with Feiteng eight methods,acupuncture 5 times a week for 4 weeks,and the control group was treated with fluoxetine hydrochloride 20 mg,once a day,assessed by Hamilton Depression scale HAMD,modified Edinburgh-Scandinavia Neurological impairment scale MESSS,activity of Daily living scale BI and adverse event recording scale.The evaluation time was before treatment and once after treatment.At the same time,the peripheral blood was detected before and after treatment,IL-6 was detected by electrochemiluminescence immunoassay,and CRP,was detected by flow cytometry at the same time as the evaluation time of the scale,that is,before and after treatment,respectively.Finally,the above scales and peripheral blood indexes were statistically analyzed.The results of the study are as follows:1.Baseline situation:A total of 70 patients with PSD were randomly divided into Feitengba method group(n=36)and fluoxetine hydrochloride group(n=34).Finally,60 effective cases were completed,10 cases were removed,0 cases were removed,and the drop rate was 14.29%.Among them,there were 6 cases in Feiteng eight method group and 4 cases in fluoxetine hydrochloride group.the final number of cases included in the data analysis set of the two groups were as follows:Feiteng eight method group(n=30)and fluoxetine hydrochloride group(n=30).There was no significant difference in gender,age,Hamilton Depression scale score,modified Edinburgh-Scandinavia neurological deficit score,activity of daily living score and peripheral blood test(IL-6,CRP)between the two groups before treatment(P >0.05).The baseline was comparable.2.Evaluation of curative effect:Measurement of price by scale,(HAMD)score of Hamilton Depression scale: intra-group comparison: after treatment,the scores of the two groups were significantly lower than those before treatment,and there was a significant difference between the two groups.(P<0.01).Comparison between groups: compared with fluoxetine hydrochloride group,Feiteng Bafa group could effectively reduce HAMD score,and the difference was highly statistically significant(P<0.01).(MESSS)score of the modified Edinburgh-Scandinavian Neurological deficit scale: comparison within the group: after treatment,the scores of the two groups were significantly lower than those before treatment,and there was a significant difference between the two groups.(P<0.01).Comparison between groups: compared with fluoxetine hydrochloride group,Feiteng Bafa group could effectively reduce MESSS score,and the difference was highly statistically significant(P<0.01).(BI)score of activities of daily living scale: comparison within the group: after treatment,The scores of the two groups were significantly higher than those before treatment,and there was a difference between the two groups.(P<0.05).Comparison between groups: compared with fluoxetine hydrochloride group,Feiteng Bafa group could effectively raise BI score,and the difference was statistically significant(P<0.05).Peripheral blood detection,C-reactive protein in(CRP): group: after treatment,the level of C-reactive protein in Feitengba method group was significantly lower than that before treatment,and that in fluoxetine hydrochloride group was significantly lower than that before treatment(P<0.05).Comparison between groups: there was no significant difference in CRP between Feiteng Bafa group and fluoxetine hydrochloride group(P>0.05).2Interleukin-6(IL-6): after treatment,the levels of IL-6 in the two groups were significantly lower than those before treatment,and there was a significant difference between the two groups.(P<0.01).Comparison between groups: compared with fluoxetine hydrochloride group,Feiteng Bafa group could effectively reduce the level of IL-6,and the difference was statistically significant(P<0.05).Research conclusions:Feiteng eight methods can effectively improve the anxiety and depressive symptoms of patients with post-stroke depression,improve their activities of daily life and reduce the defect of neurological function.And Feiteng eight methods can effectively reduce the level of inflammatory cytokines in patients with post-stroke depression.The mechanism of the above clinical efficacy may be related to the improvement of chronic inflammation in patients with post-stroke depression. |
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