Analysis Of Risk Factors For Recurrence Or Metastasis Within Six Months After Pancreaticoduodenectomy In Patients With Pancreatic Head Cancer

Background and Purpose:Pancreatic cancer is a tumor.It can say that the mortality is very high.Typically,the nature of its nature is incidental.Specifically,most of the patients have come to the late stage when the patient finds tumor.In distant organs,such as liver,the lung are compared to existing metastasis.Based on this nature,patients can say that there is no opportunity for radical surgery.The World Health Organization has conducted detailed statistics: the incidence of global malignant tumor and pancreatic cancer in 2012 was located in 13 and 7 in 13 bits and 7.Our country’s 2019 data indicates the incidence of pancreatic cancer and the 10 th and 6th place in mild tumors.To date,some risk factors for pancreatic cancer have been identified,For example,long-term smoking,drinking,obesity,genetic factors,eating habits(high-fat and high protein diet),diabetes,lack of exercise,etc.However,the specific cause is also uncertain [1].From an anatomical perspective,pancreatic cancer can be divided into two kinds,one is a pancreatic head(groatstream)cancer,and the other is pancreatic tail cancer.Head cancer often occurs,probably occupying 70%-80% of pancreatic cancer.The preferred treatment of pancreatic head cancer is still surgical to remove both pancreaticoduodenctomy(WHIPPLE).There is also a drawback after WHIPPLE surgery,that is,there is a relapse or higher transfer rate in 6 months,and the higher recurrence rate and metastatic rate after surgery have a certain relationship with preoperative related factors.This study was to receive pancreaticoduodenectomy by retrospective analysis of 60 cases of pancreatic cancer diagnosis.The risk factors and independent risk factors of pancreatic duodenal resection were analyzed,and a certain reference is provided for clinical treatment and postoperative prognosis for pancreatic head cancer.Research Methods:In 2018.10-2019.10,Julin University,60 patients with in Jilin University(before surgery,no obvious distant metastasis,intraoperative exploration of liver without transfer)Acceptance of pancreaticoduodenectomy.Patients with pancreatic head cancer are selected from the middle,and these patients have observed the possible risk factors of recurrence or metastasis within 6 months by pancreaticoduodenectomy treatment.There are several of the followings:(1)Basic information of patients,such as age,gender,smoking history,alcohol history,history of hypertension,history of diabetes and history of heart disease.(2)Laboratory examination: such as CA199,preoperative bilirubin,AST,ALT,neutrophil and lymphocytes(NLR).(3)Tumor-related factors: such as tumor size(diameter of postoperative pathology),blood-free invasion,differentiation conditions(postoperative pathology),and there is a zeal-free node transfer.(4)Surgical configuration: Laparoscopic pancreaticoduodenctomy(LPD)or conventional open pancreaticoduodenctomy(PD).(5)Postoperative adjuvant treatment: chemotherapy.Study Results:1.60 patients with pancreatic head cancer received PD and 15 cases reappeared,and the recurrence rates within half a year was 25%.2.All possible recurrence factors are single-factor analysis by the card square inspection or T inspection.P < 0.05 can be used as a standard.The results show: CA199,tumor size,vascular infringement,differentiation,whether chemotherapy after surgery is a risk factor(P<0.05).Gender,age,hypertension history,history of diabetes,history of heart disease,smoking history,alcoholic history,bilirubin,AST,Alt,neutral granuli and lymphocytes(NLR),whether there is lymph node transfer and laparoscopic surgery or open surgery with pancreatic head cancer patients in WHIPPLE surgery in half a year has nothing to do with high-end(P >0.05).3.Samples that have been analyzed by the chief test and T test need to be analyzed(P < 0.05).It is then necessary to classify it into binary Logistic regression analysis.It is also used as a standard in P <0.05.The results showed that CA199(P = 0.016),blood vessel violation(P = 0.038),whether the chemotherapy after surgery(P = 0.009)was an independent risk factor(P <0.05).Tumor size and differentiation are not independent risk factors(all P<0.05)recurrence or metastasis(P all)of patients with pancreatic(head)cancer(all P>0.05).