Study On The Relationship Between ¹¹C-PIB-PET/CT And Neuropsychological Scale In Mild Cognitive Impairment And Alzheimer’s Disease

Object:To explore the relationship between ¹¹C-PIB-PET/CT and neuropsychological scales in mild cognitive impairment and Alzheimer’s disease.Methods:Twenty-seven outpatients and inpatients with Alzheimer’s disease（AD）and mild cognitive impairment（MCI）who met the inclusion criteria were selected from our neurology department between January2018 and December 2020,and general information,neuropsychological test scale scores and ¹¹C-PIB-PET/CT imaging were collected.The standardized uptake value ratio（SUVR）of ¹¹C-PIB in each brain region of the patient was obtained by processing the patient’s ¹¹C-PIB-PET/CT imaging using p MOD software.The brain areas that were significantly different were compared between groups and the SUVR with neuropsychological test scale was statistically analyzed for the brain areas that were significantly different for all patients.Results:1.The mean value of SUVR in the AD group was higher than the mean value of SUVR in the MCI group,and the difference between groups was statistically significant（p<0.01）.2.The brain regions with significantly different SUVR values（p<0.01）between the two groups were:left inferior frontal gyrus（p=0.009）,left superior frontal gyrus（p=0.008）,left parahippocampal gyrus and perirhinal gyrus（p=0.005）,right parahippocampal gyrus and perirhinal gyrus（p=0.002）,left syrinx（p=0.002）,right syrinx（p=0.003）,left postcentral gyrus（p=0.003）,right cuneus（p=0.008）,left cisternal nucleus（p=0.007）,right cisternal nucleus（p=0.003）right pallidum（p=0.006）,and right anterior cingulate gyrus（p=0.004）.3.Further pearson correlation analysis was performed between the significantly different SUVR values of brain regions and MMSE and Mo Ca scores in all patients.Among them,the SUVR values of the left superior frontal gyrus（r=-0.454,p=0.029）,left parahippocampal gyrus and peripheral gyrus（r=-0.439,p=0.036）,left syrinx（r=-0.421,p=0.045）,and left postcentral gyrus（r=-0.482,p=0.020）were negatively correlated with MMSE scores（p<0.05）.The left superior frontal gyrus（r=-0.430,p=0.040）,left parahippocampal gyrus and peripheral gyrus（r=-0.418,p=0.047）,left cingulate gyrus（r=-0.454,p=0.030）,left postcentral gyrus（r=-0.477,p=0.021）,left cisternal nucleus（r=-0.422,p=0.045）,right cisternal nucleus（r=-0.419,p=0.047）SUVR values were negatively correlated with Mo Ca scores（p<0.05）.Conclusions:1.SUVR values of ¹¹C-PIB in the brain of patients in the AD group were significantly higher than those of patients in the MCI group.2.SUVR values in several brain regions were significantly different between patients in the AD and MCI groups.3.The levels of Aβprotein deposition in the superior frontal gyrus（left）,parahippocampal gyrus and perirhinal gyrus（left）,sphenoid gyrus（left）,postcentral gyrus（left）,and nucleus accumbens（left and right）were associated with cognitive impairment.