Discussion On The Clinical Features And The Distribution Of TCM Syndrome Types In Patients With Bronchiectasis Accompanied By Elevated Exhaled Nitric Oxide

Objective:To explore the clinical characteristics and the distribution of TCM syndromes of patients with bronchiectasis(BE)accompanied by elevated levels of exhaled nitric oxide(FeNO);It is expected to provide new ideas for the diagnosis,treatment,curative effect evaluation,and prognosis judgment of BE,and provide a reference basis for the objective diagnosis and treatment of BE.Methods:The bronchiectasis patients,who had been admitted to respiratory medicine in Hospital(T.C.M)Affiliated To Southwest Medical University from December 2018 to December 2019,were retrospectively studied and recorded in EXCEL.A total of 120 patients were enrolled,with FeNO equal to 25 ppb as the critical value,and divided into elevated group(FeNO greater than 25ppb)and non-elevated group(FeNO less than 25ppb).Retrospectively analyzing and comparing the difference of Clinical data such as gender,age,season of onset,smoking status,course of disease,hospitalization days,common complications,main clinical symptoms,sputum culture,blood routine indicators,lung function indicators,hormone using and TCM syndrome distribution in the elevated group and the non-elevated group.To explore the clinical characteristics and the distribution of TCM syndromes of patients with bronchiectasis accompanied by elevated levels of exhaled nitric oxide.Results:A total of 120 patients with bronchiectasis were included in this study,including 32 in the elevated group and 88 in the non-elevated group.1.There was no significant difference in general clinical data such as gender,age,season of onset,smoking,course of disease,hospitalization days between the elevated group and the non-elevated group(P>0.05).2.The proportion of bronchial asthma in the elevated combination was higher than that in the non-elevated group(P<0.05),and there was no significant difference in the combination of other common complications between the two groups(P>0.05).3.The proportion of dyspnea in the elevated group was higher than that in the non-elevated group(P<0.05).There was no significant difference in clinical symptoms such as fever,cough,sputum,chest pain between the two groups(P>0.05).4.There was no statistical difference between the two groups in the positive rate of sputum culture(P>0.05).5.The white blood cell count,the percentage of neutrophils,and the percentage of eosinophils in the elevated group were higher than those in the non-elevated group(P<0.05).There was no significant difference between the two groups in the percentage of lymphocytes and basophils(P>0.05).6.The percentage of the forced expiratory volume in the first second to the predicted value and the ratio of the forced expiratory volume in the first second to the total vital capacity of the elevated group were lower than those of the non-elevated group(P<0.05).7.The hormone use rate and hormone use time of the elevated group were higher than those of the non-elevated group(P<0.05).8.The TCM syndromes of the elevated group and the non-elevated group are mainly phlegm-heat obstructing lung syndrome.The proportion of each syndrome type from high to low is phlegm-heat obstructing lung syndrome,phlegm-dampness obstructing lung syndrome,lung-qi and yin deficiency syndrome,lung-spleen-qi deficiency syndrome.But there was no significant difference in the distribution of TCM syndrome types between the two groups(P>0.05).Conclusion: 1.BE Patients with elevated FeNO levels are more likely to have asthma,and clinically more likely to have decreased lung function and dyspnea.Their chronic airway inflammation may be the result of neutrophilic inflammation and eosinophilic inflammation.The application of corticosteroids is more common in BE patients with elevated FeNO.2.The distribution of TCM syndrome types of BE in descending order is phlegm-heat obstructing lung syndrome,phlegm-dampness obstructing lung syndrome,lung-qi and yin deficiency syndrome,lung-spleen-qi deficiency syndrome.There is no Correlation between the BE patient’s FeNO level and the distribution of TCM syndrome types.There is no special TCM syndrome type distribution pattern in BE patients with elevated FeNO levels.