Correlation Analysis Of Ultrasound Imaging Features And Pathology Of Benign And Malignant Thyroid Nodules

Objective:This study analyzed the ultrasonic signs of benign and malignant thyroid nodules,to explore the value of ultrasound in the differential diagnosis of benign and malignant thyroid nodules,and to provide help for the diagnosis and treatment of thyroid nodules.Methods:In this study,1749 patients who underwent thyroid surgery in Yijishan Hospital of Wannan Medical College during January 1,2015 to January 1,2020 were selected and confirmed by preoperative ultrasound examination and surgical pathology examination.Of benign and malignant thyroid nodules were retrospectively analyzed in general medical records(age,gender,etc.),benign and malignant thyroid nodules were emphatically studied on ultrasonic imaging signs,relatively benign and malignant thyroid nodules in nodules,number,size,diameter,shape,aspect ratio,internal echo,boundary,calcification,blood flow signals,with or without cervical lymph node metastasis is different,compared with or without cervical lymph node metastasis in thyroid malignant nodules of different ultrasonic signs.Calculation of color doppler ultrasound diagnosis of benign and malignant thyroid nodules,accuracy,sensitivity,specific degrees using the SPSS20.0Χ~2test and research on the software binary logistic regression analysis.Results:(1)In 1749 patients with benign and malignant thyroid nodules,all thyroid nodules were confirmed by biopsy pathology,including 866 benign nodules,883malignant nodules,and 328 male thyroid nodules,aged 13-78 years,with an average of(47.81±12.64)years.There were 1421 cases of female thyroid nodules,ranging from 15to 83 years old,with an average age of(46.44±11.60)years old.There was no significant difference between the two groups(P=0.589>0.05).(2)in patients with benign and malignant thyroid nodules ultrasonographic manifestations chi-square analysis,grow in nodule number,size,direction,shape,composition,inner echo,edge,boundary,coated,calcification and blood flow signals of ultrasonic characteristics,malignant thyroid nodules were higher than in benign thyroid nodules group,the difference was statistically significant(p<0.001).(3)variables related to statistical significance of the multi-factor logistic regression analysis,the results showed that the nodule diameter>1,the aspect ratio>1 a solid,irregular nodular morphology,composition,inner echo low echo,edge is coarse(successful Angle,leaf or a burr shape),boundary unclear,incomplete capsule,micro calcification,a central type rich blood flow is prompt independent risk factors for the development of malignant thyroid nodules,the difference was statistically significant(p<0.001).(4)The sensitivity,specificity and accuracy of color Doppler ultrasonography in the diagnosis of benign and malignant thyroid nodules were 92.52%,87.24%,89.84%,92.31%and 87.57%,respectively.The area under the ROC curve of color Doppler ultrasonography in the diagnosis of benign and malignant thyroid nodules was 0.899,which was consistent with the pathological diagnosis.The lymph node metastasis rate of thyroid carcinoma was 45.98%.The abnormal rate of cervical lymph nodes found by ultrasound was46.80%.There was a statistical difference between the two groups in men and women(P<0.001).In general,the number of women with and without thyroid cancer lymph node metastasis was higher than that of men,but the rate of cervical lymph node metastasis in men was higher than that in women.There was no significant difference in age<45 years old or≥45 years old(P=0.564>0.05),which was not statistically significant.(4)In the patients with pathologically confirmed malignant nodules in thyroid cancer,compared with the non-metastatic group,the maximum diameter of nodules in the metastatic group was>1,aspect ratio was BBB>,internal echo was not uniform,boundary was not clear,and accompanied by microcalcification in the cervical lymph node metastatic group and the non-metastatic group,and the differences between the groups were statistically significant(P<0.05).Conclusion:Color Doppler ultrasonography showed that the most valuable indicators for the diagnosis of malignant thyroid nodules were the maximum diameter of nodules>1cm,aspect ratio>1,irregular shape,solid composition,low echo,rough margin,unclear boundary,incomplete capsule,microcalcification,and rich central blood flow,etc.In patients with thyroid cancer,the maximum diameter of nodules>1cm,aspect ratio>1,uneven internal echo,unclear boundary,accompanied by microcalcification and other signs showed a high risk of cervical lymph node metastasis.These features can help clinicians to diagnose benign and malignant thyroid nodules more clearly,and contribute to the later clinical treatment and prognosis evaluation.