| Objective:Based on data mining technology,this paper summarizes the medication law of traditional Chinese medicine in the treatment of chronic duration of bronchial asthma and allergic cough in children.At the same time,to provide clinical basis for "Treating Different Diseases with the Same Treatment " in traditional Chinese Medicine theory,the article observed the clinical effect of Qingyangrunfei Prescription in treating children with CDBA-LSQDS and AC-LSQDS and compared the symptom scores before and after the treatment through clinical research.Methods:(1)Through the CNKI database,the key fields "child" and "Traditional Chinese Medicine"and "chronic duration of bronchial asthma" or "delayed asthma" or "non-attack stage of asthma" were searched for full-text advanced retrieval,and relevant literatures on the treatment of chronic duration of bronchial asthma with traditional Chinese medicine were screened;In the same way,"child" and "allergic cough",and "Traditional Chinese Medicine"or "chronic cough" or"allergic cough" were used as search terms for full-text advanced retrieval,and relevant literatures on treating allergic cough with traditional Chinese medicine were screened out.SPSS Modeler18.0 and SPSS26.0 were used for frequency analysis,association rule analysis and cluster analysis of screened TCM.(2)78 children with CDBA-LSPDS and 78 children with AC-LSPDS were included.They were divided into treatment group and control group,the treatment group was treated with the tutor’s experience prescription " Qingyangrunfei Prescription",and the control group was treated with montelukast sodium chewable tablets for 4 weeks.The improvement of total score of primary and secondary symptoms and single symptom score of children with the same TCM syndrome before and after treatment were analyzed and compared.Results:(1)On data mining technology:a total of 105 references were included in the data mining results of the treatment of CDBA by traditional Chinese medicine.Through frequency analysis,the drugs with the highest frequency of use were Huang Qi,Gan Cao,Bai Zhu,Fu Ling,etc.It formed high frequency drug combinations in children with chronic duration of bronchial asthma such as Chen pi-Fu Ling,Chen pi-Bai Zhu,Fang Feng-Huang Qi,Fang Feng-Bai Zhu,Fu Ling-Bai Zhu,as well as Banxia-Bai Zhu-Fu Ling,Banxia-Bai Zhu-Chen PI,Banxia-Fu Ling-Chen PI,Banxia-Huang Qi-Fu Ling,Banxia-Huang Qi-Bai Zhu through association rules.Clustering rules formed 7 new prescriptions.A total of 102 references were included in the data mining results of TCM treatment of AC in children.Through frequency analysis,it was concluded that the traditional Chinese medicines with the highest frequency of use were Gan Cao,Xing Ren,Chen Pi,Ban Xia,Bai Zhu,Jie Geng,etc.Through association rules,Huang Qi-Bai Zhu,Ban Xia-Jie Geng-Chen Pi,Fu Ling-Ban Xia-Chen Pi,Huang Qi-Chen Pi-Fang Feng,Fu Ling-Huang Qi-Bai Zhu,and other high-frequency drug combinations were formed.Clustering rules formed 8 new prescriptions.(2)On clinical research,in overall efficacy:after 2 weeks of treatment,the treatment group of children with CDBA-LSQDS was compared with the control group,the total effective rate of the treatment group and the control group was respectively 65%and 67%,with no significant difference between the two groups(P>0.05);After 4 weeks of treatment,the total effective rate was 85%in the treatment group and 73%in the control group,and the difference was statistically significant(P<0.05);1 month after the end of treatment,the total effective rate of the children with AC-LSQDS was 80%in the treatment group and 70%in the control group,and the difference was statistically significant(P<0.05).After 2 weeks of treatment,the total effective rate was 80%in the treatment group and 60%in the control group,and the difference was statistically significant(P<0.05);After 4 weeks of treatment,the total effective rate was 89%in the treatment group and 73%in the control group,and the difference was statistically significant(P<0.05);1 month after the end of treatment,the total effective rate was 87%in the treatment group and 67%in the control group,and the difference was statistically significant(P<0.05).(3)Observation on the curative effect of children with CDBA-LSPDS:After 2 and 4 weeks of treatment,the total scores of primary symptoms and secondary symptoms of the treatment group and the control group were significantly different from those before treatment(P<0.01).After 2 weeks of treatment,compared with the control group,the improvement of asthma,nasal itching,pharyngeal itching,spirit,complexion,appetite,stool and urine symptoms in the treatment group was statistically significant(P<0.05),but there was no statistical difference in cough,chest tightness,nasal congestion,runny nose and sneezing symptoms between the two groups(P>0.05).After 4 weeks of treatment,the improvement of cough,chest tightness,pharyngeal itching,sneezing,spirit,complexion,appetite,defecation and urination in the treatment group was significantly different from those in the control group(P<0.05),but there was no significant difference in asthma,nasal congestion,nasal itching and runny nose between the two groups(P<0.05).(4)Observation on the curative effect of children with AC-LSPDS:After 2 and 4 weeks of treatment,the total scores of main and secondary symptoms in the treatment group and the control group were significantly different from those before treatment(P<0.01).After 2 weeks of treatment,compared with the control group,there was significant difference in the improvement of night cough,pharyngeal itching,complexion,spirit,stool and urination between the two groups(P<0.05),but there was no significant difference in the improvement of daytime cough,expectoration,nasal congestion,nasal itching,runny nose,sneezing,appetite and food intake(P>0.05);After 4 weeks of treatment,compared with the control group,there was significant difference in the improvement of daytime cough,nighttime cough,pharyngeal itching,complexion,appetite,feces and urination between the two groups(P<0.05),but there was no significant difference in the improvement of expectoration,nasal congestion,nasal itching,runny nose,sneezing and spirit(P>0.05).Conclusion:In a word,it is in line with clinical practice to treat children with CDBA and AC with lung and spleen as the core.Qingyangrunfei Prescription has good clinical effect in treating children with lung and spleen qi deficiency syndrome of CDBA and AC,which provides a new idea for the treatment of children with lung allergic diseases and enriches the connotation of treating different diseases with the same treatment. |
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