| Objective: The decrease of retinal and choroid blood flow in myopia patients has a great influence on the progress of myopia and the occurrence of myopia complications.Finding drugs that affect the blood flow of the retina and choroid is an important measure for myopia defense.In this study,coherent optical tomography angiography(OCTA)was used to observe the effects of tropicamide phenylephrine eye drops on retinal vessel density and subfoveal choroidal thickness in children and adolescents before and after pupil dilation.Methods: This was a prospective clinical study comprising 144 eyes of 72 adolescents aged between 4 and 14 years.All participants were dilated with tropicamide phenylephrine eye drops and underwent comprehensive ophthalmic examinations.Then,the eyes were scanned with a 3*3mm scan line in the horizontal and vertical directions using OCTA.Image J software was used to measure the retinal blood flow density at each layer and the choroidal thickness was measured by optical coherence tomographyenhanced depth imaging mode,and the collected data were analyzed by SPSS paired sample t-test,one-way analysis of variance and multivariate analysis to compare the compound tropikamide drops in different age groups and different refractive powers.The difference of eye fluid on the changes of retinal and choroidal blood flow density and choroidal thickness.Results: 1.After dilated pupil with topicamide phenylephrine eye drops,the superficial retinal blood flow density in macular area was significantly decreased(P < 0.001),while the choroidal vascular density was increased(P < 0.001).Groups according to age,and the low age group with high age,middle age compared with high age of shallow retinal blood flow density change was statistically significant(P < 0.05),the differences in the changes of choroidal blood flow density among the low,middle,and high age groups were statistically significant among the three groups(P < 0.05).Grouped by dioptre,low,medium and high myopia shallow retinal blood flow changes comparing differences between three groups had statistical significance(P < 0.01),the difference in choroid blood flow between low and high myopia was statistically significant(P <0.05).2.The choroidal thickness under macular central fovea was increased after dilated pupil with topicamide phenylephrine compared with that before infusion(P< 0.001).In the horizontal axis,the choroidal thickness increased except for 1.5mm on the nasal side of the fovea(P<0.001).In the upper and lower axis,the thickness of the choroid has increased,and the thickness of the lower choroid has increased greatly,and the increase is most obvious at 1.5mm below the central fovea(P <0.001).Grouped by age,there was a statistically significant difference in choroidal thickness between the low-age group and the high-age group(P<0.05).Grouped by refractive power,there was a statistically significant difference in choroidal thickness between low-and high-myopia groups(P<0.05).3.The choroidal thickness in the macular area is significantly thicker from the nasal side to the temporal side(P <0.001),and the choroidal thickness in the lower part is significantly thicker than the upper one(P <0.001).4.The results of multivariate analysis showed that age is the main factor affecting the changes of superficial retina and choroidal blood flow density and choroidal thickness of compound tropikamide eye drops.Conclusion: Tropicamide phenylephrine eye drops can significantly increase choroidal thickness and choroidal vascular density in low age and low diopter children and adolescents,which can temporarily relieve the decrease of choroidal blood flow in patients due to myopia.Age is the main factor affecting choroidal thickness.It is necessary to further study whether compound topicamide eye drops can intervene and prevent the development of myopia and delay the occurrence of myopia complications. |
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