Analysing Functional Dyspepsia Medication Rules Of Professor Shan Zhaowei By Data Mining

Objective:On the basis of the medical records for the treatment of functional dyspepsia by Professor Shan Zhaowei,this study intends to analyze medication rules for the treatment of functional dyspepsia via data mining,aiming to provide clinical references.Methods:The clinical data of patients with functional dyspepsia treated by Professor Shan Zhaowei in the outpatient department of Jiangsu Province Hospital of Chinese Medicine from October 2016 to November 2020 was collected.A database was established by putting data into Excel,and data of 483 patients in total was processed by correction,supplementation and standardization.Frequency statistics,cluster analysis along with factor analysis were performed by IBM SPSS Statistics 26.0 software,and correlation analysis was performed by IBM SPSS Modeler 18.0 software.The results were analyzed combined with practical experience of diagnosis and treatment of Professor Shan Zhaowei.Results:Out of 483 cases,there were 271 females and 212 males,the obvious age accumulated in 30 to 59 years.The main differentiated TCM syndromes were spleen deficiency and Qi stagnation,dampness and heat of spleen and stomach,and disharmony between liver and stomach,accounting for 30.6%(148 cases),29.2%(141 cases)and 24.0%(116 cases),respectively.The herbs with the function of tonifying weakness were the most frequently used,followed by those with functions of regulating qi,tranquilizing spirit,eliminating phlegm,dispersing dampness,and clearing heat.Related factor analysis and correlation analysis of the top 54 high-frequency herbs in combination showed that 8 herb-partners by compatibility were most important partners,such as Baihe-Fushen,Heye-Zexie.Based on correlation analysis on the 6 TCM syndromes of functional dyspepsia and cluster analysis on the top 29 highly-frequently herbs,core prescriptions of functional dyspepsia were yielded.Liujunzi Decoction,Self-made Heat-clearing and Qi-reinforcing Decoction,Self-made Chaihu-Shaoyao Protecting Membrane Decoction,Yiwei Decoction,Yiguan Decoction,Banxia Xiexin Decoction,Lizhong Pill,Huangqi Jianzhong Decoction with increased or decreased compositions were the core prescriptions of functional dyspepsia.According to external symptoms,the prescriptions for different subtypes of functional dyspepsia differed from each other,for example,the patients with postprandial discomfort syndrome were treated by herbs with the functions of regulating qi and dredging as well as descending of stomach-qi,strengthening the spleen and increasing appetite,and regulating qi and promoting digestion,but those with epigastric pain syndrome were usually additionally treated by herbs functioning in relieving acute symptoms and pain,and relieving acid and pain.Conclusions:In the treatment of functional dyspepsia,Professor Shan Zhaowei considers that the weakness of spleen and stomach is the root cause of functional dyspepsia,therefore tonifying spleen and improving transportation is taken as basic treatment.Besides,he emphasizes on the therapies of soothing liver and regulating blood,and at the same time,clearing heat and eliminating dampness during its treatment,along with warming meridians and dispersing cold,nourishing yin by herbs flavored in sweat and cold,regulation of cold and heat,promoting blood circulation and removing blood stasis in combination are also applied for treatment of external symptoms.Therefore,he believes that therapeutic points are combination of syndrome and disease differentiation,skillful application of herb-partners,mastery of typical concurrent disease,and assistance of descending and ascending of qi activity during treatment.