| Objective:To compare the clinical efficacy and safety of electroacupuncture,solifenacin and sham electroacupuncture in the treatment for women with urgency-predominant mixed urinary incontinence.Methods:A total of 48 women with urgency-predominant mixed urinary incontinence were collected in the study,all of whom were enrolled in the acupuncture and rehabilitation department,urology department and gynecology department of Jiangsu Hospital of Traditional Chinese Medicine from March 2019 to March 2021.Using the central random data system,they were randomly divided into three groups,16 cases in the electroacupuncture group,1 case fell out,15 cases actually;In the solifenacin group of 16 cases,1 case fell off,which was actually 15 cases.Of the 16 cases in the sham electroacupuncture group,1 case fell off,which was actually 15 cases.Electroacupuncture group was given deep acupuncture on both sides of the Zhongliao、Huiyang and Sanyinjiao points,3 times a week,1 time every other day,30 minutes each time.Solifenacin group was taken orally once a day,each time 1 tablet.The sham electroacupuncture group was treated with non-meridian and non-acupoint(bilateral Zhongliao level opened 1 inch,bilateral Huiyang level opened 1 inch,bilateral Sanyinjiao and Achilles tendon level line midpoint)shallow acupuncture,3 times a week,once every other day,30 minutes each time.All three groups were treated for 12 weeks and followed up for 12 weeks.The number of urgent urinary incontinence for 72 hours,the number of mixed urinary incontinence,ICIQ-SF scale,OAB-q SF scale,PGI-I scale and adverse reactions were compared before and after treatment among women with urgency-predominant mixed urinary incontinence.Results:1.72h Urgent Urinary Incontinence:Compared with previous treatment,there were statistically significant differences in each evaluation period of the electroacupuncture group and the solifenacin group(P<0.05);Compared with previous treatment,there was statistically significant difference in the sham electroacupuncture group after 4 and 8 weeks of treatment(P<0.05),but there was no statistically significant difference between before and after 12 weeks of treatment(P>0.05).The follow-up period of the three groups was significantly different from that previous treatment(P<0.05).There was no significant difference between the electroacupuncture group and the solifenacin group in the number of Urgent Urinary Incontinence 72h at the 12th week of the treatment period between the three groups(P>0.05),and the efficacy of the two groups was basically the same.Compared with the sham electroacupuncture group,the difference was statistically significant(P<0.05).The curative effect of the electroacupuncture group and the solifenacin group was better than that of the sham electroacupuncture group-In the aspects of the number of urgent urinary incontinence during the follow-up period of 72h,the treatment of the electroacupuncture group and the solifenacin group compared with the micro-electroacupuncture group was statistically significant(P<0.05).There was no significant difference between the solifenacin group and the sham acupuncture group(P>0.05).2.72h frequency of mixed urinary incontinence:Compared with previous treatment,there were statistically significant differences in each evaluation period of the electroacupuncture group(P<0.05);Compared with previous treatment,there were statistically significant differences in solifenacin group and sham electroacupuncture group after 8 weeks and 12 weeks(P<0.05).The follow-up period of the three groups was significantly different from that previous treatment(P<0.05).Among the three groups,there was statistically significant difference in the frequency of mixed urinary incontinence at 72h during the 12th week of treatment(P<0.05)between the electroacupuncture group and the sham electroacupuncture group,while there was no statistically significant difference of the electroacupuncture group and the sham electroacupuncture group,compared with the solifenacin group(P>0.05).Compared with the number of mixed urinary incontinence in the three groups during the follow-up period of 72h,the difference of the electroacupuncture group was statistically significant(P<0.05).,comparing with the solifenacin group and the sham electroacupuncture group There was no significant difference between the solifenacin group and the sham acupuncture group(P>0.05).3.ICIQ-SF score:There were significant differences in each evaluation period of electroacupuncture group and solifenacin group after 4 and 12 weeks treatment(P<0.05),but there was no significant difference between sham electroacupuncture and pre-treatment in each evaluation period(P>0.05),There were significant differences between electroacupuncture group and solifenacin group during the follow-up period(P<0.05),but there was no significant difference between sham electroacupuncture group during the follow-up period(P>0.05).In terms of ICIQ-SF score at the 12th week of treatment among the three groups,there was significant difference of the electroacupuncture group and the solifenacin group,comparing with the sham electroacupuncture group,but there was no significant difference between the electroacupuncture group and the solifenacine group(P>0.05).There was significant difference in the number of mixed urinary incontinence between electroacupuncture group and sham electroacupuncture group during 72 hours follow-up period among the three groups(P<0.05),but there was no significant difference of solifenacin group,comparing with the electroacupuncture group and sham electroacupuncture group(P>0.05).4.The urination urgency correlation score of OAB-q SF scale:There were significant differences in each evaluation period of electroacupuncture group and solifenacin group compared with those before treatment(P<0.05),but there was no significant difference in sham electroacupuncture group(P>0.05).There were significant differences in each electroacupuncture group and solifenacin group during the follow-up period compared with that before treatment(P<0.05).There was no significant difference between sham electroacupuncture during the follow-up period and before treatment(P>0.05).In terms of the urination urgency correlation score of OAB-q SF scale at the 12th week of treatment among the three groups,there was significant difference of the electroacupuncture group and the solifenacin group,comparing with the sham electroacupuncture group(P<0.05),but there was no significant difference between the electroacupuncture group and the solifenacin group(P>0.05).During the follow-up period,there was significant difference in the score of urination urgency correlation between electroacupuncture group and sham electroacupuncture group,but there was no significant difference of solifenacin group,comparing with electroacupuncture group and sham electroacupuncture group(P>0.05).5.The scores related to quality of life of OAB-q SF scale:There was significant difference in each evaluation period of electroacupuncture group compared with that before treatment(P<0.05).The solifenacin group had significant difference after 8 weeks and 12 weeks treatment compared with that before treatment,but there was no significant difference in each evaluation period of sham electroacupuncture between before and after treatment(P>0.05).There were significant differences between electroacupuncture group and solifenacin group during the follow-up period(P<0.05),but there was no significant difference of sham electroacupuncture group during the follow-up period(P>0.05).In terms of quality of life related scores of OAB-q SF scale at the 12th week of treatment among the three groups,there was significant difference of electroacupuncture group and solifenacin group,comparing with sham electroacupuncture group(P<0.05),but there was no significant difference between electroacupuncture group and solifenacin group(P>0.05).During the follow-up period,there was significant difference in the score of urination urgency correlation between electroacupuncture group and sham electroacupuncture group,but there was no significant difference of solifenacin group,comparing with electroacupuncture group and sham electroacupuncture group(P>0.05).6.PGI-I score of subjective cure rate:the subjective cure rate of the electroacupuncture group and the solifenacin group were better than the sham electroacupuncture group during the treatment and follow-up period,and the subjective cure rate of the electroacupuncture group was higher than that of the solifenacin group.Conclusions:1.Electroacupuncture at Zhongliao,Huiyang and Sanyinjiao acupoints can effectively improve the number of urgent urinary incontinence and mixed urinary incontinence in women with urgency-predominant mixed urinary incontinence,and improve the quality of life of patients.2.At the 12th week of treatment,the efficacy of electroacupuncture group and solifenacin group in improving the frequency of urgent urinary incontinence,ICIQ-SF score,PGI-I score and OAB-QSF scale was similar,and they were all superior to the sham electroacupuncture group;In the follow-up period,the efficacy of electroacupuncture in improving the number of urgent urinary incontinence,the number of mixed urinary incontinence and PGI-I score was better than that of solifenacin group and sham electroacupuncture group.3.Electroacupuncture treatment has no obvious adverse reactions,and it is a green therapy worthy of clinical promotion. |
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