Clinical Observation Of Danzhi Xiaoyao Powder Modified Combined With Jiangu Pill In Treating Postmenopausal Osteoporosis With Anxiety Disorder Of Kidney Deficiency And Liver Stagnation

Objective:This study observes the treatment of postmenopausal osteoporosis patients with kidney-deficiency and liver-stagnation combined with anxiety by using Danzhi Xiaoyao Powder and Jiangu Pills,the Hamilton Anxiety Scale,TCM syndrome score,VAS and serum estrogen before and after treatment(FSH,E2)level,bone mineral density,bone metabolism index(serum osteocalcin,25-hydroxyvitamin D)changes,observe Danzhi Xiaoyao powder combined with Jiangu pills in the treatment of postmenopausal osteoporosis combined with kidney deficiency and liver depression The clinical efficacy of anxiety disorders.Methods:(1)According to the intake and discharge criteria,60 patients with menopausal osteoporosis and anxiety were selected,and basic information such as height and weight of the patients were recorded,and various biochemical indicators such as bone metabolism and estrogen were measured.At the same time,observe the patient’s bone mineral density and Hamilton Anxiety Disorder Scale and other indicators.(2)Select the postmenopausal osteoporosis patients with anxiety who meet the inclusion and exclusion criteria,and randomly divide them into the experimental group and the control group with 30 cases each.The control group is given Alfacalcidol capsules 0.25ug once a day.The experimental group was given Danzhi Xiaoyao Powder plus or minus(1 dose per day,200ml water decoction,twice in the morning and evening)combined with Jiangu Pill 5g,once a day in the morning and evening,and the treatment course was observed for 6 months.Mainly observe the improvement of symptoms before and after treatment,as well as bone density,bone metabolism indicators(osteocalcin,25-hydroxyvitamin D),estrogen levels(estradiol,follicle stimulating hormone),Hamilton anxiety scale and TCM syndrome score Variety.Result:(1)Correlation analysis:After treatment,the TCM syndrome score and the total score of the test group were better than those before treatment,and the difference was statistically significant(P<0.05);but there was a difference in sleep quality and hot flashes and sweating.No statistical significance(P>0.05);the improvement the control of VAS pain score in the treatment group was obviously better than that in the control group,and the difference met the statistical value(P<0.05).The control of HAMA pain score in the experimental group was obviously better than that in the control group,and the difference met the statistical value(P<0.05).After the treatment,through the comparative analysis within the osteocalcin group,it was found that the two groups participated in the treatment Before treatment,there was obvious remission;after the treatment,in the comparison within the osteocalcin group,the treatment group and the control group were significantly improved compared to before treatment,and the difference was statistically significant(P<0.05).Between the osteocalcin groups In comparison,the improvement of patients in the In the comparison of 25 hydroxyvitamin D3,the patients in the experimental group had significant remission compared with those before the participation,and the difference met the statistical value(P<0.05);in the comparison and analysis between 25 hydroxyvitamin D3 groups,the remission effect of the patients in the experimental group was more prominent,and the difference met the statistical value(P<0.05);in the experimental group,the difference met the statistical value There was significant remission before participation,and the difference met the statistical value(P<0.05);the improvement of patients in the treatment group was better than that before treatment in the same group,and the difference was statistically significant(P<0.05);Before the bone mineral density team performed related treatment activities,the test group patients improved and the control group before the related treatment activities,there is no difference between the group data of this part and there is a corresponding statistical value(P>0.05);in the relevant treatment activities Afterwards,the comparison between the two groups,the test group and the control group have improved,but the comparison of the group data in this part has a corresponding statistical value(P<0.05);In comparison within the E2 group,both the treatment group and the control group have improved significantly compared to before treatment,and the difference is statistically significant(P<0.05).In terms of comparison between the E2 groups,the improvement of patients in the treatment group is better than that of the control group.,The difference is statistically significant(P<0.05);in terms of FSH comparison,patients in the treatment group and the control group have significantly improved compared with before treatment,and the difference is statistically significant(P<0.05);the comparison between the two groups of patients found that,The difference was not statistically significant(P>0.05);in the treatment group,in the control group,there were 8 cases with obvious effect,12 cases with certain effect,and 10 cases with invalid part.The clinical treatment of the two groups passed the corresponding test process.According to the results,it was recognized that there were significant differences in the distribution of treatment effect between the two groups,and the differences met the statistical requirements Academic value.The results suggest that the difference in the distribution of clinical efficacy between the two groups of patients is statistically significant(P<0.05),and the clinical effectiveness of the treatment group is significantly better than that of the control group.Conclusion:(1)Danzhi Xiaoyao Powder can significantly improve clinical symptoms and adjust estrogen levels in the treatment of liver depression type anxiety.(2)Jiangu Pills can effectively improve clinical symptoms in the treatment of postmenopausal osteoporosis patients.In the bone metabolism index,it can increase the content of osteocalcin and vitamin D,increase the rate of bone formation,and promote reduction of bone resorption.Reduce bone destruction and maintain the balance of bone metabolism.(3)Danzhi Xiaoyao Pills combined with Jiangu Pills are effective in treating menopausal osteoporosis with anxiety(suppression of kidney and liver depression),which can effectively improve clinical symptoms,regulate body bone metabolism,sex hormone levels,anxiety,and improve patients Quality of Life.Modified Zhixiaoyao Pills combined with Jiangu Pills are safer for the treatment of menopausal osteoporosis with anxiety,and are worthy of clinical application.