Clinical Study Of Jiawei Tongluo Prescription In The Treatment Of Deficiency Of Qi And Blood Stasis Combined With Deficiency Of Yin In Convalescent Period Of Cerebral Infarction

ObjectiveThrough prospective controlled clinical trials,this study observed the clinical efficacy of Jiawei Tongluo Formula on patients with Qi deficiency and blood stasis combined with Yin deficiency syndrome in the convalescence period of cerebral infarction,providing new ideas and basis for the prevention and treatment of cerebral infarction in the convalescence period,and further improving the series of clinical studies on the application of Jiawei Tongluo Formula in the treatment of cerebral infarction under the guidance of the theory of"Three Syndrome Combined Disease".MethodIn this study,72 patients with cerebral infarction convalescence meeting the inclusion criteria were selected and divided into experimental group and control group according to random number table method,with 36 cases in each group for a course of 4 weeks.The experimental group was given Jiawei Tongluo prescription and western medicine routine treatment,while the control group was given western medicine routine treatment.The scores of National Institutes Health Stroke Scale(NIHSS),Barthel Index(BI),Modified Rankin Scale(MRS),Stroke efficacy evaluation score,and TCM symptom grading Scale(Qi deficiency and blood stasis syndrome,Yin deficiency syndrome)were recorded before treatment and at the end of the fourth week of treatment.Result1.There were no significant differences in age,gender and NIHSS scores between the two groups(P>0.05),indicating that the two groups were comparable.2.There was no significant difference in NIHSS scores between the two groups before treatment(P>0.05),but there was a significant difference in NIHSS scores between the experimental group and the control group after treatment(P<0.05),and there was a significant difference in NIHSS scores between the two groups before and after treatment(P<0.05).Comparison within groups:NIHSS scores of the experimental group before and after treatment were significantly different(P<0.05),and those of the control group before and after treatment were significantly different(P<0.05).3.There was no significant difference in BI scores between the two groups before treatment(P>0.05),but there was significant difference in BI scores between the experimental group and the control group after treatment(P<0.05),and there was significant difference in BI scores between the two groups before and after treatment(P<0.05).Intra-group comparison:there were significant differences in BI scores before and after treatment in the experimental group(P<0.05),and there were significant differences in BI scores in the control group(P<0.05).4.There was no significant difference in MRS score between the two groups before treatment(P>0.05),but there was significant difference in MRS score between the experimental group and the control group after treatment(P<0.05).Comparison within groups:there were significant differences in MRS scores before and after treatment in the experimental group(P<0.05),and there were significant differences in MRS scores before and after treatment in the control group(P<0.05).5.There was no significant difference in the syndrome scores of qi deficiency and blood stasis between the two groups before treatment(P>0.05),but there was significant difference in the syndrome scores of qi deficiency and blood stasis between the experimental group and the control group after treatment(P<0.05),and significant difference in the syndrome scores of qi deficiency and blood stasis between the two groups before and after treatment(P<0.05).Comparison within the groups:there was a significant diference in the syndrome scores of qi deficiency and blood stasis in the experimental group before and after treatment(P<0.05),and there was a significant difference in the syndrome scores of qi deficiency and blood stasis in the control group before and after treatment(P<0.05).6.There was no significant difference in Yin deficiency syndrome scores between the two groups before treatment(P>0.05).After treatment,there was a significant difference in Yin deficiency syndrome scores between the experimental group and the control group(P<0.05).There was a significant difference in Yin deficiency syndrome scores between the two groups before and after treatment(P<0.05).Intra-group comparison:there was significant difference in the syndrome scores of Yin deficiency before and after treatment in the experimental group(P<0.05),and there was significant difference in the syndrome scores of Yin deficiency before and after treatment in the control group(P<0.05).7.There was no significant difference in the scores of stroke efficacy evaluation between the two groups before treatment(P<0.05),but there was significant difference in the scores of stroke efficacy evaluation between the experimental group and the control group after treatment(P<0.05),and there was significant difference in the scores of stroke efficacy evaluation between the two groups before and after treatment(P<0.05).Intra-group comparison:there was a significant difference in the scores of stroke efficacy evaluation before and after treatment in the experimental group(P<0.05),and there was a significant difference in the scores of stroke efficacy evaluation before and after treatment in the control group(P<0.05).8.Efficacy comparison:In the experimental group,34 cases were effective,20 cases were effective,55.6%effective and 97.7%total effective.In the control group,a total of 28 cases were effective,5 cases were effective,the significant efficiency was 13.8%,the total effective rate was 77.8%.Mann-Whitney U test showed that there was a significant difference in the overall efficacy between the two groups after treatment(P<0.05).Chi-square test showed that there were significant differences in significant efficiency and total effective rate between the two groups(P<0.05).ConclusionJiawei Tonglu Formula can improve the neurological function deficit of patients with qi deficiency and blood stasis combined with Yin deficiency in the convalesce period of cerebral infarction,improve the ability of daily living activities,reduce the degree of disability,and effectively improve the score of qi deficiency and blood stasis,Yin deficiency syndrome and the score of therapeutic effect evaluation of stroke disease.The overall efficacy,significant efficiency and total effective rate of jiaweitongluo prescription group were better than those of control group,and the safety was better.