Study On The Regulation Of Different Light On The Lifespan Of Drosophila

With the rapid development of national economy,people’s living standard has been greatly improved.People begin to pay more and more attention to health problems and pursue health care and anti-aging products.At the same time,with the development of science and technology,people have a deeper understanding of the impact of living environment,living environment requirements have also been improved to some extent.As an important part of living environment,illumination is ubiquitous in people’s life and production,and it is also one of the essential conditions in the cultivation of most experimental animal models.Although visible light is generally considered harmless,light also plays a role in circadian rhythms,neuromodulation,endocrinology,and many studies have shown that light plays a role in regulating health.The effects of invisible light on aging have been extensively studied.However,humans and research organisms are commonly exposed to visible light,and its role remains largely unknown.Especially when animal models are used for research,spectral quality,wavelength,intensity and so on May affect experimental results.By studying the effects of different wavelength and intensity of light on the life span,food intake,microbial action,anti-stress ability,activity,and antioxidant ability of two genotypes of Drosophila(white eyes w¹¹¹⁸,red eyes Canton-S),the regulation effect of light on the life span of Drosophila was investigated.The results showed that the effect of visible light on Drosophila lifespan was wavelength specific,with green light significantly extending lifespan,blue light significantly reducing lifespan,and red light having a slight effect.In addition,although caloric restriction,oxidative stress,or activity did not contribute to the beneficial effects of green light,our study found that the life span extension effect of green light might be mediated by microbiota or photosensitive micronutrients in food medium.In conclusion,this paper shows the different effects of different light exposures on the lifespan of Drosophila,especially the green light can extend longevity,and present the potential of light as a noninvasive therapy for aging-related diseases.