Clinical Observation Of Qushi Jiedu Recipe Combined With Entecavir In The Treatment Of Damp-heat Internal Junction Chronic Hepatitis B

Objective: to explore the clinical efficacy of Qushi jiedu recipe combined with entecavir in the treatment of damp-heat internal junction chronic hepatitis B.Methods: sixty patients with damp-heat internal junction chronic hepatitis B treated in Huang Dao traditional Chinese Medicine Hospital from October 2019 to February 2021 were randomly divided into experimental group(n = 30)and control group(n = 30).The experimental group was treated with Qushi jiedu recipe combined with entecavir dispersible tablets,while the control group was treated with entecavir dispersible tablets only.The clinical symptoms and signs,liver function,HBVDNA replication,liver fibrosis and comprehensive therapeutic effect of the two groups were observed.Results:1.The TCM syndrome efficacy index of patients in the experimental group was 96.7%,while that of the control group was 30%.The experimental group was significantly better than the control group,with a very significant difference(P<0.01).2.There was a very significant difference in the scores of main TCM symptoms in the experimental group before and after treatment(P<0.01).After treatment,there was a very significant difference in the score of main symptoms between the two groups(P<0.01).3.The level of liver function in the experimental group was better than that in the control group after treatment,and the difference was significant(P<0.05).4.There was a very significant difference in the content of HBV DNA in the experimental group before and after treatment,but there was no significant difference between the two groups after treatment.5.There was a very significant difference in the four items of liver fibrosis in the experimental group before and after treatment(P<0.01).After treatment,the experimental group was better than the control group(P<0.01).6.In terms of clinical comprehensive curative effect of the two groups,the total effective rate of the experimental group was 83.3% and that of the control group was 30%.The clinical comprehensive curative effect of the experimental group was significantly better than that of the control group(P<0.01).Conclusion:Qushi jiedu recipe combined with entecavir is effective in the treatment of damp-heat internal junction chronic hepatitis B.