Comparison Of Target Organ Damage Between OSAHS With Hypertension And Essential Hypertension

Objective:Of OSAHS with hypertension with target organ damage in patients with primary hypertension,preliminary discussion of OSAHS cause or aggravate hypertension risk factors,for OSAHS combined hypertension target-organ damage prevention and provide experimental evidence for individualized treatment for such patients.Method:Collected from October 1,2018 to October 31,2020 in the Fuwai Cardiovascular Hospital of Yunnan Province inpatients underwent polysomnography monitoring,and complete data of 127 patients with just-needed need,taking the apnea hypopnea index as Grouping basis,divided into light-medium OSAHS group(AHI 5-30 times/h),severe OSAHS group(AHI≥30 times/h)and essential hypertension group(AHI<5 times/h,and exclusion OSAHS)three groups;analyze the general data,serological indexes,echocardiographic indexes,arteriosclerosis indexes,24-hour ambulatory blood pressure monitoring indexes,and polysomnography data of the above three groups,compare the differences between the three groups,and explore OSAHS and left ventricle The correlation between hypertrophy,arteriosclerosis,and ambulatory blood pressure.Results:1.Comparison of age and HCY between the three groups was statistically significant(P<0.05);Comparison of BMI,percentage of patients with diabetes,GHB,FPG,UA in the three groups,the differences were statistically significant(P<0.01);Pairwise comparison,compared with primary hypertension group,the rest of the two groups of older,BMI and severe OSAHS group,available,FPG,UA is higher,the difference was statistically significant(P<0.05),severe OSAHS group of HCY,GHB,higher than light to moderate OSAHS group,the difference was statistically significant(P<0.05).2.Comparison of the three groups of LVEDD,the difference was statistically significant(P<0.05);the three groups of LVEF,IVST,LVPW,RWT,LVM,LVMI-height2.7,the percentage of each heart configuration,the difference was not statistically significant(P>0.05).Pairwise comparison,compared with the essential hypertension group,the severe OSAHS group had greater LVEDD,and the difference was statistically significant(P<0.05).OSAHS with hypertension than in primary hypertension group,the number of left ventricular hypertrophy percentage is higher,but the number of detected with two groups of left ventricular hypertrophy,there was no statistically significant difference(P>0.05).3.Comparison of the three groups of bilateral baPWV,the difference was statistically significant(P<0.05);the comparison of the three groups of bilateral CIMT,the difference was significant(P<0.01);the differences of the three groups of bilateral ABI were not statistically significant(P>0.05).Pairwise comparison,the result shows,compared with the essential hypertension group,the light-medium OSAHS group of bilateral baPWV,and the severe OSAHS group of LbaPWV were faster,and the difference was statistically significant(P<0.05);Compared with the essential hypertension group,the bilateral CIMT in the mild-moderate OSAHS group,and the bilateral CIMT in the severe OSAHS group were thicker,and the difference was statistically significant(P<0.01).4.The three groups of 24SBP,dSBP,nSBP,EMSBP,MHSBP,the difference was statistically significant(P<0.05);the three groups of 24DBP,dDBP,nDBP,EMDBP,MHDBP,the difference was not statistically significant(P>0.05).Pairwise comparison,24SBP,dSBP,and EMSBP were higher in the severe OSAHS group compared with the essential hypertension group,and the difference was statistically significant(P<0.05).5.Three groups of 24SBPSD,dSBPCV comparison,the difference statistically significant(P<0.05);Three groups of dSBPSD comparison,there are significant difference statistically significant(P<0.01);The rest of the index difference had no statistical significance(P>0.05).Pairwise comparison,compared with essential hypertension group,severe OSAHS group and 24SBPSD,dSBPSD,dSBPSD and light to moderate OSAHS group and dSBPCV bigger,differences were statistically significant(P<0.05).6.Three groups of diastolic blood pressure circadian rhythm each ratio difference was statistically significant(P<0.05);The number of abnormal blood pressure circadian rhythms in the OSAHS combined with hypertension group was more than that in essential hypertension group,the difference was statistically significant(P<0.05).7.ODI,TS90%,TS-90,LSpO2,number of apneas,total apnea time,and longest apnea time in the severe OSAHS group were higher than those in the mild-moderate OSAHS group,and the differences were extremely significant(P<0.001).8.LSpO2 was negatively correlated with nSBPSD and nSBPCV(P<0.05),and was significantly correlated with nSBPSD(P<0.01);AHI was positively correlated with RCIMT(P<0.05).Conclusions:1.OSAHS combined with hypertension is more prone to atherosclerosis,and the thickness of the carotid artery intima-media is positively correlated with AHI;2.Glycated hemoglobin and homocysteine increase with the severity of OSAHS;3.OSAHS combined with hypertension are more prone to abnormal blood pressure circadian rhythm,increased blood pressure variability(mainly systolic blood pressure),increased blood pressure level(mainly systolic blood pressure),morning blood pressure(mainly systolic blood pressure),and blood pressure variability the degree is negatively correlated with the minimum oxygen saturation at night.