| Objective:In this study,neonatal 25-hydroxyvitamin D(25(OH)D),serum total bilirubin(TBIL),indirecit bilirubin(IBIL),direct bilirubin(DBIL),PCT and CRP were detected.Analyze and compare the levels of serum 25(OH)D in neonates with infectious jaundice,neonates with non-infectious jaundice,and neonates with non-jaundice,explore the relationship between bilirubin levels and 25(OH)D levels.Methods:Using prospective research methods,66 full-term newborns hospitalized in the Second Affiliated Hospital of Kunming Medical University from September 2020 to December 2020 were collected as research objects.According to gestational age,the causes and inflammatory indexes of jaundice were divided into infectious jaundice group(n=26)and non-infectious jaundice group(n=40).Twenty-one full-term newborns without jaundice were randomly selected as control group.Peripheral venous blood was collected from all newborns after admission for serum 25-(OH)D,PCT,CRP and biochemical tests.SPSS23.0 was used for statistical analysis.Results:1.The average gestational age of newborns in infectious jaundice group wa s 39.80±0.91 weeks,the average birth weight was 3244±358g,the proportion o f 25(OH)D deficiency was 31%(n=8),and the proportion of insufficient was 46%(n=12),the sufficient proportion is 23%(n=6).Serum 25(OH)D levels i n infectious jaundice group and control group were 15.27±6.14ng/ml,18.90±5.70ng/ml respectively,the difference was statistically significant(t=-2.077,P<0.05).2.The average gestational age of newborns in non-infectious jaundice grou p was 39.45±1.19 weeks,the average birth weight was 3217.375±335g,the pro portion of 25(OH)D deficiency was 37.5%(n=15),and the proportion of insu fficient was 47.5%(n=19),the sufficient proportion is 15%(n=6).The serum 25(OH)D levels of non-infectious jaundice group and control group were 14.13±5.24ng/ml,18.90+5.70ng/ml respectively,the difference was statistically signif icant(t=-3.278,P<0.05).3.The Serum 25(OH)D levels of infectious jaundice group and non-infectious jaundice group were 15.27±6.14 ng/ml and 14.13±5.24 ng/ml,respectively,the difference was not statistically significant(t=0.812,P>0.05);the serum PCT levels of infectious jaundice group and non-infectious jaundice group were 2.54±3.69ng/ml and 0.79±1.45 ng/ml respectively,the difference was statistically significant(P<0.05);The serum CRP levels of infectious jaundice group and non-infectious jaundice group were 6.67±8.99mg/L and1.23±1.66mg/L,respectively,and the difference was statistically significant(P<0.05).4.In the infectious jaundice group,the serum 25(OH)D level and serum total bilirubin(R2=0.010,P>0.05),indirect bilirubin(R2=0.0059,P>0.05)and direct bilirubin levels(R2=0.019,P>0.05)are not relevant.5.The serum 25(OH)D level in the non-infectious jaundice group has no correlation with serum total bilirubin(R2=0.040,P>0.05)and indirect bilirubin(R2=2.5×105,P>0.05),But there is a negative correlation with the direct bilirubin level(R2=0.166,P<0.05),and the linear correlation between the two is weak.6.The serum 25(OH)D level in the infectious jaundice group was not correlated with PCT(R2=0.030,P>0.05)and CRP(R2=0.008,P>0.05).Conclusion(s):1.The level of 25(OH)D in children with jaundice was lower than that in children without jaundice,and there was no correlation between the level of serum 25(OH)D and the level of serum bilirubin in the jaundice group;2.There was no significant difference in serum 25(OH)D levels between infectious jaundice group and non-infectious jaundice group.3.The level of 25(OH)D in infectious jaundice group has no correlation with PCT and CRP. |
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