Expression Of HDAC2 And Acetylated P53^k320 In Colon Cancer And Their Correlation With Clinicopathology

Objective:To detect the expression of HDAC2 and acetylated p53^k320 in colon cancer,analyse their relationship with clinicopathological parameters and their correlation in colon cancer,so as to provide new ideas for the treatment of colon cancer.Methods:According to the exclusion criteria,patients with colon cancer were selected to collect cancer tissue samples,and normal volunteers were recruited to collect normal colonic mucosa tissue,Western blot was used to detect the expression of HDAC2 and acetylated p53^k320 in colon cancer and normal colon mucosa;Chi square test was used to compare the expression of HDAC2 and acetylated p53^k320 in different clinicopathological parameters;The correlation between HDAC2 and acetylated p53^k320 was analyzed by person correlation analysis.Results:（1）The expression of HDAC2 was 1.6±0.04 in colon cancer and 0.29±0.06,compared with normal colon mucosa,the expression of HDAC2 in colon cancer tissue was up-regulated,and the difference was statistically significant（P<0.05）;（2）The expression level of acetylated p53^k320in colon cancer was 0.1±0.01 and 0.78±0.02 in normal colon mucosa,compared with normal colon mucosa,the expression of acetylated p53^k320 was down regulated in colon cancer tissues,and the difference was statistically significant（P<0.05）;（3）The expression of HDAC2 and acetylated p53^k320 in colon cancer was related to the size of the tumor（P<0.05）,the degree of differentiation（P<0.05）,lymph node metastasis（P<0.05）and TNM stage（P<0.05）;（4）There was a negative correlation between HDAC2 and acetylated p53^k320in colon cancer tissues（P<0.05、r=-0.364）.Conclusions:（1）Compared with normal colon mucosa,HDAC2 was highly expressed in colon cancer tissues,while acetylated p53^k320 was low expressed in colon cancer tissues;（2）The larger the tumor,the lower the degree of differentiation,lymph node metastasis and TNM stage,the higher the expression of HDAC2 and the lower the expression of acetylated p53^k320;（3）There was a negative correlation between HDAC2 and acetylated p53^k320 in colon cancer tissues（P<0.05、r=-0.364）.